Easton J - Search Results

1

Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

Thimmaiah KN, Easton J, Huang S, Veverka KA, Germain GS, Harwood FC, Houghton PJ. Thimmaiah KN, et al. Among authors: easton j. Cancer Res. 2003 Jan 15;63(2):364-74. Cancer Res. 2003. PMID: 12543789

2

Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma.

Easton J, Wei T, Lahti JM, Kidd VJ. Easton J, et al. Cancer Res. 1998 Jun 15;58(12):2624-32. Cancer Res. 1998. PMID: 9635589

3

Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1).

Huang S, Shu L, Dilling MB, Easton J, Harwood FC, Ichijo H, Houghton PJ. Huang S, et al. Among authors: easton j. Mol Cell. 2003 Jun;11(6):1491-501. doi: 10.1016/s1097-2765(03)00180-1. Mol Cell. 2003. PMID: 12820963 Free article.

4

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.

Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ. Huang S, et al. Among authors: easton j. J Biol Chem. 2004 Aug 27;279(35):36490-6. doi: 10.1074/jbc.M401208200. Epub 2004 Jun 24. J Biol Chem. 2004. PMID: 15218033 Free article.

5

Therapeutic potential of target of rapamycin inhibitors.

Easton JB, Houghton PJ. Easton JB, et al. Expert Opin Ther Targets. 2004 Dec;8(6):551-64. doi: 10.1517/14728222.8.6.551. Expert Opin Ther Targets. 2004. PMID: 15584862 Review.

6

Virtual docking approaches to protein kinase B inhibition.

Forino M, Jung D, Easton JB, Houghton PJ, Pellecchia M. Forino M, et al. Among authors: easton jb. J Med Chem. 2005 Apr 7;48(7):2278-81. doi: 10.1021/jm048962u. J Med Chem. 2005. PMID: 15801821

7

Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.

Thimmaiah KN, Easton JB, Germain GS, Morton CL, Kamath S, Buolamwini JK, Houghton PJ. Thimmaiah KN, et al. Among authors: easton jb. J Biol Chem. 2005 Sep 9;280(36):31924-35. doi: 10.1074/jbc.M507057200. Epub 2005 Jul 11. J Biol Chem. 2005. PMID: 16009706 Free article.

8

IRS-1: auditing the effectiveness of mTOR inhibitors.

Easton JB, Kurmasheva RT, Houghton PJ. Easton JB, et al. Cancer Cell. 2006 Mar;9(3):153-5. doi: 10.1016/j.ccr.2006.02.027. Cancer Cell. 2006. PMID: 16530700 Free article. Review.

9

The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor.

Easton JB, Royer AR, Middlemas DS. Easton JB, et al. J Neurochem. 2006 May;97(3):834-45. doi: 10.1111/j.1471-4159.2006.03789.x. Epub 2006 Mar 29. J Neurochem. 2006. PMID: 16573649 Free article.

10

mTOR and cancer therapy.

Easton JB, Houghton PJ. Easton JB, et al. Oncogene. 2006 Oct 16;25(48):6436-46. doi: 10.1038/sj.onc.1209886. Oncogene. 2006. PMID: 17041628 Review.

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