Steffan JS - Search Results

1

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Hockly E, Richon VM, Woodman B, Smith DL, Zhou X, Rosa E, Sathasivam K, Ghazi-Noori S, Mahal A, Lowden PA, Steffan JS, Marsh JL, Thompson LM, Lewis CM, Marks PA, Bates GP. Hockly E, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2041-6. doi: 10.1073/pnas.0437870100. Epub 2003 Feb 7. Proc Natl Acad Sci U S A. 2003. PMID: 12576549 Free PMC article.

2

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM. Steffan JS, et al. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6763-8. doi: 10.1073/pnas.100110097. Proc Natl Acad Sci U S A. 2000. PMID: 10823891 Free PMC article.

3

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.

Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM. Steffan JS, et al. Nature. 2001 Oct 18;413(6857):739-43. doi: 10.1038/35099568. Nature. 2001. PMID: 11607033

4

Histone deacetylase inhibitors reduce polyglutamine toxicity.

McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH. McCampbell A, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15179-84. doi: 10.1073/pnas.261400698. Epub 2001 Dec 11. Proc Natl Acad Sci U S A. 2001. PMID: 11742087 Free PMC article.

5

A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila.

Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. Kazantsev A, et al. Among authors: steffan js. Nat Genet. 2002 Apr;30(4):367-76. doi: 10.1038/ng864. Epub 2002 Mar 25. Nat Genet. 2002. PMID: 11925563

6

Targeting aggregation in the development of therapeutics for the treatment of Huntington's disease and other polyglutamine repeat diseases.

Steffan JS, Thompson LM. Steffan JS, et al. Expert Opin Ther Targets. 2003 Apr;7(2):201-13. doi: 10.1517/14728222.7.2.201. Expert Opin Ther Targets. 2003. PMID: 12667098 Review.

7

SUMO modification of Huntingtin and Huntington's disease pathology.

Steffan JS, Agrawal N, Pallos J, Rockabrand E, Trotman LC, Slepko N, Illes K, Lukacsovich T, Zhu YZ, Cattaneo E, Pandolfi PP, Thompson LM, Marsh JL. Steffan JS, et al. Science. 2004 Apr 2;304(5667):100-4. doi: 10.1126/science.1092194. Science. 2004. PMID: 15064418

8

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins.

Slepko N, Bhattacharyya AM, Jackson GR, Steffan JS, Marsh JL, Thompson LM, Wetzel R. Slepko N, et al. Among authors: steffan js. Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14367-72. doi: 10.1073/pnas.0602348103. Epub 2006 Sep 15. Proc Natl Acad Sci U S A. 2006. PMID: 16980414 Free PMC article.

9

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

Rockabrand E, Slepko N, Pantalone A, Nukala VN, Kazantsev A, Marsh JL, Sullivan PG, Steffan JS, Sensi SL, Thompson LM. Rockabrand E, et al. Among authors: steffan js. Hum Mol Genet. 2007 Jan 1;16(1):61-77. doi: 10.1093/hmg/ddl440. Epub 2006 Nov 29. Hum Mol Genet. 2007. PMID: 17135277

10

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

Pallos J, Bodai L, Lukacsovich T, Purcell JM, Steffan JS, Thompson LM, Marsh JL. Pallos J, et al. Among authors: steffan js. Hum Mol Genet. 2008 Dec 1;17(23):3767-75. doi: 10.1093/hmg/ddn273. Epub 2008 Sep 1. Hum Mol Genet. 2008. PMID: 18762557 Free PMC article.

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