Costantino G - Search Results

1

Novel isoquinolinone-derived inhibitors of poly(ADP-ribose) polymerase-1: pharmacological characterization and neuroprotective effects in an in vitro model of cerebral ischemia.

Chiarugi A, Meli E, Calvani M, Picca R, Baronti R, Camaioni E, Costantino G, Marinozzi M, Pellegrini-Giampietro DE, Pellicciari R, Moroni F. Chiarugi A, et al. Among authors: costantino g. J Pharmacol Exp Ther. 2003 Jun;305(3):943-9. doi: 10.1124/jpet.103.048934. Epub 2003 Feb 20. J Pharmacol Exp Ther. 2003. PMID: 12606624

2

Towards new neuroprotective agents: design and synthesis of 4H-thieno[2,3-c] isoquinolin-5-one derivatives as potent PARP-1 inhibitors.

Pellicciari R, Camaioni E, Costantino G, Marinozzi M, Macchiarulo A, Moroni F, Natalini B. Pellicciari R, et al. Among authors: costantino g. Farmaco. 2003 Sep;58(9):851-8. doi: 10.1016/S0014-827X(03)00143-5. Farmaco. 2003. PMID: 13679179

3

On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.

Pellicciari R, Camaioni E, Costantino G, Formentini L, Sabbatini P, Venturoni F, Eren G, Bellocchi D, Chiarugi A, Moroni F. Pellicciari R, et al. Among authors: costantino g. ChemMedChem. 2008 Jun;3(6):914-23. doi: 10.1002/cmdc.200800010. ChemMedChem. 2008. PMID: 18409175

4

Modeling of poly(ADP-ribose)polymerase (PARP) inhibitors. Docking of ligands and quantitative structure-activity relationship analysis.

Costantino G, Macchiarulo A, Camaioni E, Pellicciari R. Costantino G, et al. J Med Chem. 2001 Nov 8;44(23):3786-94. doi: 10.1021/jm010116l. J Med Chem. 2001. PMID: 11689065

5

3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.

Pellicciari R, Camaioni E, Costantino G. Pellicciari R, et al. Among authors: costantino g. Prog Med Chem. 2004;42:125-69. doi: 10.1016/S0079-6468(04)42003-7. Prog Med Chem. 2004. PMID: 15003720 Review. No abstract available.

6

Docking studies on PARP-1 inhibitors: insights into the role of a binding pocket water molecule.

Bellocchi D, Macchiarulo A, Costantino G, Pellicciari R. Bellocchi D, et al. Among authors: costantino g. Bioorg Med Chem. 2005 Feb 15;13(4):1151-7. doi: 10.1016/j.bmc.2004.11.024. Bioorg Med Chem. 2005. PMID: 15670923

7

Poly(ADP-ribose)-polymerase-catalyzed hydrolysis of NAD+: QM/MM simulation of the enzyme reaction.

Bellocchi D, Costantino G, Pellicciari R, Re N, Marrone A, Coletti C. Bellocchi D, et al. Among authors: costantino g. ChemMedChem. 2006 May;1(5):533-9. doi: 10.1002/cmdc.200500061. ChemMedChem. 2006. PMID: 16892389

8

Modulation of glutamate receptor pathways in the search for new neuroprotective agents.

Pellicciari R, Costantino G, Marinozzi M, Natalini B. Pellicciari R, et al. Among authors: costantino g. Farmaco. 1998 Apr;53(4):255-61. doi: 10.1016/s0014-827x(98)00018-4. Farmaco. 1998. PMID: 9658582 Review.

9

Metabotropic glutamate receptors: structure and new subtype-selective ligands.

Pellicciari R, Costantino G, Marinozzi M, Macchiarulo A, Camaioni E, Natalini B. Pellicciari R, et al. Among authors: costantino g. Farmaco. 2001 Jan-Feb;56(1-2):91-4. doi: 10.1016/s0014-827x(01)01006-0. Farmaco. 2001. PMID: 11347974 Review.

10

Rat brain guanosine binding site. Biological studies and pseudo-receptor construction.

Traversa U, Bombi G, Camaioni E, Macchiarulo A, Costantino G, Palmieri C, Caciagli F, Pellicciari R. Traversa U, et al. Among authors: costantino g. Bioorg Med Chem. 2003 Dec 1;11(24):5417-25. doi: 10.1016/j.bmc.2003.09.043. Bioorg Med Chem. 2003. PMID: 14642586

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