Aoki K - Search Results

1

Enhancement of therapeutic protein in vivo activities through glycoengineering.

Elliott S, Lorenzini T, Asher S, Aoki K, Brankow D, Buck L, Busse L, Chang D, Fuller J, Grant J, Hernday N, Hokum M, Hu S, Knudten A, Levin N, Komorowski R, Martin F, Navarro R, Osslund T, Rogers G, Rogers N, Trail G, Egrie J. Elliott S, et al. Among authors: aoki k. Nat Biotechnol. 2003 Apr;21(4):414-21. doi: 10.1038/nbt799. Epub 2003 Mar 3. Nat Biotechnol. 2003. PMID: 12612588

2

Efficiency of signalling through cytokine receptors depends critically on receptor orientation.

Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J, Finer-Moore J, Elliott S, Sitney K, Katz BA, Matthews DJ, Wendoloski JJ, Egrie J, Stroud RM. Syed RS, et al. Among authors: aoki kh. Nature. 1998 Oct 1;395(6701):511-6. doi: 10.1038/26773. Nature. 1998. PMID: 9774108

3

Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role.

Agoram B, Aoki K, Doshi S, Gegg C, Jang G, Molineux G, Narhi L, Elliott S. Agoram B, et al. Among authors: aoki k. J Pharm Sci. 2009 Jun;98(6):2198-211. doi: 10.1002/jps.21578. J Pharm Sci. 2009. PMID: 18837016

4

NMR structure of human erythropoietin and a comparison with its receptor bound conformation.

Cheetham JC, Smith DM, Aoki KH, Stevenson JL, Hoeffel TJ, Syed RS, Egrie J, Harvey TS. Cheetham JC, et al. Among authors: aoki kh. Nat Struct Biol. 1998 Oct;5(10):861-6. doi: 10.1038/2302. Nat Struct Biol. 1998. PMID: 9783743

5

Asn to Lys mutations at three sites which are N-glycosylated in the mammalian protein decrease the aggregation of Escherichia coli-derived erythropoietin.

Narhi LO, Arakawa T, Aoki K, Wen J, Elliott S, Boone T, Cheetham J. Narhi LO, et al. Among authors: aoki k. Protein Eng. 2001 Feb;14(2):135-40. doi: 10.1093/protein/14.2.135. Protein Eng. 2001. PMID: 11297671

6

Characterization and biological effects of recombinant human erythropoietin.

Egrie JC, Strickland TW, Lane J, Aoki K, Cohen AM, Smalling R, Trail G, Lin FK, Browne JK, Hines DK. Egrie JC, et al. Among authors: aoki k. Immunobiology. 1986 Sep;172(3-5):213-24. doi: 10.1016/S0171-2985(86)80101-2. Immunobiology. 1986. PMID: 3542810

7

Changes in conformation and stability upon formation of complexes of erythropoietin (EPO) and soluble EPO receptor.

Narhi LO, Aoki KH, Philo JS, Arakawa T. Narhi LO, et al. Among authors: aoki kh. J Protein Chem. 1997 Apr;16(3):213-25. doi: 10.1023/a:1026330909461. J Protein Chem. 1997. PMID: 9155092

8

The effect of carbohydrate on the structure and stability of erythropoietin.

Narhi LO, Arakawa T, Aoki KH, Elmore R, Rohde MF, Boone T, Strickland TW. Narhi LO, et al. Among authors: aoki kh. J Biol Chem. 1991 Dec 5;266(34):23022-6. J Biol Chem. 1991. PMID: 1744097 Free article.

9

Dimerization of the extracellular domain of the erythropoietin (EPO) receptor by EPO: one high-affinity and one low-affinity interaction.

Philo JS, Aoki KH, Arakawa T, Narhi LO, Wen J. Philo JS, et al. Among authors: aoki kh. Biochemistry. 1996 Feb 6;35(5):1681-91. doi: 10.1021/bi9524272. Biochemistry. 1996. PMID: 8634300

10

Engineering a soluble extracellular erythropoietin receptor (EPObp) in Pichia pastoris to eliminate microheterogeneity, and its complex with erythropoietin.

Zhan H, Liu B, Reid SW, Aoki KH, Li C, Syed RS, Karkaria C, Koe G, Sitney K, Hayenga K, Mistry F, Savel L, Dreyer M, Katz BA, Schreurs J, Matthews DJ, Cheetham JC, Egrie J, Giebel LB, Stroud RM. Zhan H, et al. Among authors: aoki kh. Protein Eng. 1999 Jun;12(6):505-13. doi: 10.1093/protein/12.6.505. Protein Eng. 1999. PMID: 10388848

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