Martin JA - Search Results

1

Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors.

Parkes KE, Ermert P, Fässler J, Ives J, Martin JA, Merrett JH, Obrecht D, Williams G, Klumpp K. Parkes KE, et al. Among authors: martin ja. J Med Chem. 2003 Mar 27;46(7):1153-64. doi: 10.1021/jm020334u. J Med Chem. 2003. PMID: 12646026

2

Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors.

Klumpp K, Hang JQ, Rajendran S, Yang Y, Derosier A, Wong Kai In P, Overton H, Parkes KE, Cammack N, Martin JA. Klumpp K, et al. Among authors: martin ja. Nucleic Acids Res. 2003 Dec 1;31(23):6852-9. doi: 10.1093/nar/gkg881. Nucleic Acids Res. 2003. PMID: 14627818 Free PMC article.

3

Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.

Smith DB, Martin JA, Klumpp K, Baker SJ, Blomgren PA, Devos R, Granycome C, Hang J, Hobbs CJ, Jiang WR, Laxton C, Le Pogam S, Leveque V, Ma H, Maile G, Merrett JH, Pichota A, Sarma K, Smith M, Swallow S, Symons J, Vesey D, Najera I, Cammack N. Smith DB, et al. Among authors: martin ja. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6. doi: 10.1016/j.bmcl.2007.02.004. Epub 2007 Feb 4. Bioorg Med Chem Lett. 2007. PMID: 17317178

4

Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.

Martin JA, Lambert RW, Merrett JH, Parkes KE, Thomas GJ, Baker SJ, Bushnell DJ, Cansfield JE, Dunsdon SJ, Freeman AC, Hopkins RA, Johns IR, Keech E, Simmonite H, Walmsley A, Wong Kai-In P, Holland M. Martin JA, et al. Bioorg Med Chem Lett. 2001 Jul 9;11(13):1655-8. doi: 10.1016/s0960-894x(01)00256-6. Bioorg Med Chem Lett. 2001. PMID: 11425530

5

A sensitive, single-tube assay to measure the enzymatic activities of influenza RNA polymerase and other poly(A) polymerases: application to kinetic and inhibitor analysis.

Hooker L, Strong R, Adams R, Handa B, Merrett JH, Martin JA, Klumpp K. Hooker L, et al. Among authors: martin ja. Nucleic Acids Res. 2001 Jul 1;29(13):2691-8. doi: 10.1093/nar/29.13.2691. Nucleic Acids Res. 2001. PMID: 11433013 Free PMC article.

6

Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1).

Martin JA, Bushnell DJ, Duncan IB, Dunsdon SJ, Hall MJ, Machin PJ, Merrett JH, Parkes KE, Roberts NA, Thomas GJ, et al. Martin JA, et al. J Med Chem. 1990 Aug;33(8):2137-45. doi: 10.1021/jm00170a015. J Med Chem. 1990. PMID: 2165161

7

Synthesis and antiviral activity of metabolites of rimantadine.

Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Manchand PS, et al. Among authors: martin ja. J Med Chem. 1990 Jul;33(7):1992-5. doi: 10.1021/jm00169a029. J Med Chem. 1990. PMID: 2362279

8

The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.

Klumpp K, Lévêque V, Le Pogam S, Ma H, Jiang WR, Kang H, Granycome C, Singer M, Laxton C, Hang JQ, Sarma K, Smith DB, Heindl D, Hobbs CJ, Merrett JH, Symons J, Cammack N, Martin JA, Devos R, Nájera I. Klumpp K, et al. Among authors: martin ja. J Biol Chem. 2006 Feb 17;281(7):3793-9. doi: 10.1074/jbc.M510195200. Epub 2005 Nov 29. J Biol Chem. 2006. PMID: 16316989 Free article.

9

Application of the phosphoramidate ProTide approach to 4'-azidouridine confers sub-micromolar potency versus hepatitis C virus on an inactive nucleoside.

Perrone P, Luoni GM, Kelleher MR, Daverio F, Angell A, Mulready S, Congiatu C, Rajyaguru S, Martin JA, Levêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C. Perrone P, et al. Among authors: martin ja. J Med Chem. 2007 Apr 19;50(8):1840-9. doi: 10.1021/jm0613370. Epub 2007 Mar 17. J Med Chem. 2007. PMID: 17367121

10

First example of phosphoramidate approach applied to a 4'-substituted purine nucleoside (4'-azidoadenosine): conversion of an inactive nucleoside to a submicromolar compound versus hepatitis C virus.

Perrone P, Daverio F, Valente R, Rajyaguru S, Martin JA, Lévêque V, Le Pogam S, Najera I, Klumpp K, Smith DB, McGuigan C. Perrone P, et al. Among authors: martin ja. J Med Chem. 2007 Nov 1;50(22):5463-70. doi: 10.1021/jm070362i. Epub 2007 Oct 3. J Med Chem. 2007. PMID: 17914786

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