Grainger DJ - Search Results

1

Broad-spectrum chemokine inhibitors (BSCIs) and their anti-inflammatory effects in vivo.

Grainger DJ, Reckless J. Grainger DJ, et al. Biochem Pharmacol. 2003 Apr 1;65(7):1027-34. doi: 10.1016/s0006-2952(02)01626-x. Biochem Pharmacol. 2003. PMID: 12663038 Review.

2

Design, synthesis, and preliminary pharmacological evaluation of N-acyl-3-aminoglutarimides as broad-spectrum chemokine inhibitors in vitro and anti-inflammatory agents in vivo.

Fox DJ, Reckless J, Warren SG, Grainger DJ. Fox DJ, et al. Among authors: grainger dj. J Med Chem. 2002 Jan 17;45(2):360-70. doi: 10.1021/jm010984i. J Med Chem. 2002. PMID: 11784140

3

Tools for anti-inflammatory drug design: in vitro models of leukocyte migration.

Frow EK, Reckless J, Grainger DJ. Frow EK, et al. Among authors: grainger dj. Med Res Rev. 2004 May;24(3):276-98. doi: 10.1002/med.10062. Med Res Rev. 2004. PMID: 14994365 Review.

4

Identification of 3-(acylamino)azepan-2-ones as stable broad-spectrum chemokine inhibitors resistant to metabolism in vivo.

Fox DJ, Reckless J, Wilbert SM, Greig I, Warren S, Grainger DJ. Fox DJ, et al. Among authors: grainger dj. J Med Chem. 2005 Feb 10;48(3):867-74. doi: 10.1021/jm049365a. J Med Chem. 2005. PMID: 15689171

5

Broad spectrum chemokine inhibitors related to NR58-3.14.3.

Grainger DJ, Reckless J, Fox DJ. Grainger DJ, et al. Mini Rev Med Chem. 2005 Sep;5(9):825-32. doi: 10.2174/1389557054867101. Mini Rev Med Chem. 2005. PMID: 16178724 Review.

6

Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.

Fox DJ, Reckless J, Lingard H, Warren S, Grainger DJ. Fox DJ, et al. Among authors: grainger dj. J Med Chem. 2009 Jun 11;52(11):3591-5. doi: 10.1021/jm900133w. J Med Chem. 2009. PMID: 19425597

7

Identification of oligopeptide sequences which inhibit migration induced by a wide range of chemokines.

Reckless J, Grainger DJ. Reckless J, et al. Among authors: grainger dj. Biochem J. 1999 Jun 15;340 ( Pt 3)(Pt 3):803-11. Biochem J. 1999. PMID: 10359667 Free PMC article.

8

The pan-chemokine inhibitor NR58-3.14.3 abolishes tumour necrosis factor-alpha accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo.

Reckless J, Tatalick LM, Grainger DJ. Reckless J, et al. Among authors: grainger dj. Immunology. 2001 Jun;103(2):244-54. doi: 10.1046/j.1365-2567.2001.01228.x. Immunology. 2001. PMID: 11412312 Free PMC article.

9

Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice.

Grainger DJ, Reckless J, McKilligin E. Grainger DJ, et al. J Immunol. 2004 Nov 15;173(10):6366-75. doi: 10.4049/jimmunol.173.10.6366. J Immunol. 2004. PMID: 15528376

10

Broad-spectrum chemokine inhibition reduces vascular macrophage accumulation and collagenolysis consistent with plaque stabilization in mice.

Reckless J, Tatalick L, Wilbert S, McKilligin E, Grainger DJ. Reckless J, et al. Among authors: grainger dj. J Vasc Res. 2005 Nov-Dec;42(6):492-502. doi: 10.1159/000088139. Epub 2005 Sep 7. J Vasc Res. 2005. PMID: 16155365

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