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In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats.
Pozeg ZI, Michelakis ED, McMurtry MS, Thébaud B, Wu XC, Dyck JR, Hashimoto K, Wang S, Moudgil R, Harry G, Sultanian R, Koshal A, Archer SL. Pozeg ZI, et al. Among authors: koshal a. Circulation. 2003 Apr 22;107(15):2037-44. doi: 10.1161/01.CIR.0000062688.76508.B3. Epub 2003 Apr 14. Circulation. 2003. PMID: 12695303
Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels.
Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, Platonov M, Koshal A, Hashimoto K, Campbell WB, Falck JR, Michelakis ED. Archer SL, et al. Among authors: koshal a. Circulation. 2003 Feb 11;107(5):769-76. doi: 10.1161/01.cir.0000047278.28407.c2. Circulation. 2003. PMID: 12578883
72 results