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In vivo gene transfer of the O2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats.
Pozeg ZI, Michelakis ED, McMurtry MS, Thébaud B, Wu XC, Dyck JR, Hashimoto K, Wang S, Moudgil R, Harry G, Sultanian R, Koshal A, Archer SL. Pozeg ZI, et al. Among authors: mcmurtry ms. Circulation. 2003 Apr 22;107(15):2037-44. doi: 10.1161/01.CIR.0000062688.76508.B3. Epub 2003 Apr 14. Circulation. 2003. PMID: 12695303
Preferential expression and function of voltage-gated, O2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells.
Archer SL, Wu XC, Thébaud B, Nsair A, Bonnet S, Tyrrell B, McMurtry MS, Hashimoto K, Harry G, Michelakis ED. Archer SL, et al. Among authors: mcmurtry ms. Circ Res. 2004 Aug 6;95(3):308-18. doi: 10.1161/01.RES.0000137173.42723.fb. Epub 2004 Jun 24. Circ Res. 2004. PMID: 15217912
An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension.
Bonnet S, Michelakis ED, Porter CJ, Andrade-Navarro MA, Thébaud B, Bonnet S, Haromy A, Harry G, Moudgil R, McMurtry MS, Weir EK, Archer SL. Bonnet S, et al. Among authors: mcmurtry ms. Circulation. 2006 Jun 6;113(22):2630-41. doi: 10.1161/CIRCULATIONAHA.105.609008. Epub 2006 May 30. Circulation. 2006. PMID: 16735674
83 results