Lear JD - Search Results

1

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.

Li R, Mitra N, Gratkowski H, Vilaire G, Litvinov R, Nagasami C, Weisel JW, Lear JD, DeGrado WF, Bennett JS. Li R, et al. Among authors: lear jd. Science. 2003 May 2;300(5620):795-8. doi: 10.1126/science.1079441. Science. 2003. PMID: 12730600

2

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.

Li R, Babu CR, Valentine K, Lear JD, Wand AJ, Bennett JS, DeGrado WF. Li R, et al. Among authors: lear jd. Biochemistry. 2002 Dec 31;41(52):15618-24. doi: 10.1021/bi026822l. Biochemistry. 2002. PMID: 12501190

3

Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles.

Lear JD, Gratkowski H, Adamian L, Liang J, DeGrado WF. Lear JD, et al. Biochemistry. 2003 Jun 3;42(21):6400-7. doi: 10.1021/bi020573j. Biochemistry. 2003. PMID: 12767221

4

Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes.

Li R, Gorelik R, Nanda V, Law PB, Lear JD, DeGrado WF, Bennett JS. Li R, et al. Among authors: lear jd. J Biol Chem. 2004 Jun 18;279(25):26666-73. doi: 10.1074/jbc.M314168200. Epub 2004 Apr 2. J Biol Chem. 2004. PMID: 15067009 Free article.

5

A push-pull mechanism for regulating integrin function.

Li W, Metcalf DG, Gorelik R, Li R, Mitra N, Nanda V, Law PB, Lear JD, Degrado WF, Bennett JS. Li W, et al. Among authors: lear jd. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1424-9. doi: 10.1073/pnas.0409334102. Epub 2005 Jan 25. Proc Natl Acad Sci U S A. 2005. PMID: 15671157 Free PMC article.

6

Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.

Yin H, Litvinov RI, Vilaire G, Zhu H, Li W, Caputo GA, Moore DT, Lear JD, Weisel JW, Degrado WF, Bennett JS. Yin H, et al. Among authors: lear jd. J Biol Chem. 2006 Dec 1;281(48):36732-41. doi: 10.1074/jbc.M605877200. Epub 2006 Oct 10. J Biol Chem. 2006. PMID: 17032655 Free article.

7

Computational design of peptides that target transmembrane helices.

Yin H, Slusky JS, Berger BW, Walters RS, Vilaire G, Litvinov RI, Lear JD, Caputo GA, Bennett JS, DeGrado WF. Yin H, et al. Among authors: lear jd. Science. 2007 Mar 30;315(5820):1817-22. doi: 10.1126/science.1136782. Science. 2007. PMID: 17395823

8

Asparagine-mediated self-association of a model transmembrane helix.

Choma C, Gratkowski H, Lear JD, DeGrado WF. Choma C, et al. Among authors: lear jd. Nat Struct Biol. 2000 Feb;7(2):161-6. doi: 10.1038/72440. Nat Struct Biol. 2000. PMID: 10655620

9

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains.

Li R, Babu CR, Lear JD, Wand AJ, Bennett JS, DeGrado WF. Li R, et al. Among authors: lear jd. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12462-7. doi: 10.1073/pnas.221463098. Epub 2001 Oct 16. Proc Natl Acad Sci U S A. 2001. PMID: 11606749 Free PMC article.

10

Experimental and computational evaluation of forces directing the association of transmembrane helices.

Zhang Y, Kulp DW, Lear JD, DeGrado WF. Zhang Y, et al. Among authors: lear jd. J Am Chem Soc. 2009 Aug 19;131(32):11341-3. doi: 10.1021/ja904625b. J Am Chem Soc. 2009. PMID: 19722646

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