Collinson N - Search Results

1

Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition.

Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, Hobbs SC, Marshall G, Maubach KA, Pillai GV, Reeve AJ, MacLeod AM. Chambers MS, et al. Among authors: collinson n. J Med Chem. 2003 May 22;46(11):2227-40. doi: 10.1021/jm020582q. J Med Chem. 2003. PMID: 12747794

2

Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, Collinson N, Dawson GR, Castro JL, MacLeod AM. Sternfeld F, et al. Among authors: collinson n. J Med Chem. 2004 Apr 22;47(9):2176-9. doi: 10.1021/jm031076j. J Med Chem. 2004. PMID: 15084116

3

An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties.

Chambers MS, Atack JR, Carling RW, Collinson N, Cook SM, Dawson GR, Ferris P, Hobbs SC, O'connor D, Marshall G, Rycroft W, Macleod AM. Chambers MS, et al. Among authors: collinson n. J Med Chem. 2004 Nov 18;47(24):5829-32. doi: 10.1021/jm040863t. J Med Chem. 2004. PMID: 15537339

4

Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.

Atack JR, Hutson PH, Collinson N, Marshall G, Bentley G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR. Atack JR, et al. Among authors: collinson n. Br J Pharmacol. 2005 Feb;144(3):357-66. doi: 10.1038/sj.bjp.0706056. Br J Pharmacol. 2005. PMID: 15655523 Free PMC article.

5

An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.

Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, Seabrook GR, Atack JR. Dawson GR, et al. Among authors: collinson n. J Pharmacol Exp Ther. 2006 Mar;316(3):1335-45. doi: 10.1124/jpet.105.092320. Epub 2005 Dec 2. J Pharmacol Exp Ther. 2006. PMID: 16326923

6

An inverse agonist selective for alpha5 subunit-containing GABAA receptors improves encoding and recall but not consolidation in the Morris water maze.

Collinson N, Atack JR, Laughton P, Dawson GR, Stephens DN. Collinson N, et al. Psychopharmacology (Berl). 2006 Nov;188(4):619-28. doi: 10.1007/s00213-006-0361-z. Epub 2006 Apr 22. Psychopharmacology (Berl). 2006. PMID: 16633803

7

Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.

Collinson N, Kuenzi FM, Jarolimek W, Maubach KA, Cothliff R, Sur C, Smith A, Otu FM, Howell O, Atack JR, McKernan RM, Seabrook GR, Dawson GR, Whiting PJ, Rosahl TW. Collinson N, et al. J Neurosci. 2002 Jul 1;22(13):5572-80. doi: 10.1523/JNEUROSCI.22-13-05572.2002. J Neurosci. 2002. PMID: 12097508 Free PMC article.

8

Development of subtype selective GABAA modulators.

Dawson GR, Collinson N, Atack JR. Dawson GR, et al. Among authors: collinson n. CNS Spectr. 2005 Jan;10(1):21-7. doi: 10.1017/s1092852900009871. CNS Spectr. 2005. PMID: 15618944 Review.

9

On the elevated plus-maze the anxiolytic-like effects of the 5-HT(1A) agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT(1A) partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635.

Collinson N, Dawson GR. Collinson N, et al. Psychopharmacology (Berl). 1997 Jul;132(1):35-43. doi: 10.1007/s002130050317. Psychopharmacology (Berl). 1997. PMID: 9272757

10

Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice.

Sur C, Wafford KA, Reynolds DS, Hadingham KL, Bromidge F, Macaulay A, Collinson N, O'Meara G, Howell O, Newman R, Myers J, Atack JR, Dawson GR, McKernan RM, Whiting PJ, Rosahl TW. Sur C, et al. Among authors: collinson n. J Neurosci. 2001 May 15;21(10):3409-18. doi: 10.1523/JNEUROSCI.21-10-03409.2001. J Neurosci. 2001. PMID: 11331371 Free PMC article.

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