Andrews DM - Search Results

1

The design of potent, non-peptidic inhibitors of hepatitis C protease.

Andrews DM, Chaignot HM, Coomber BA, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Eur J Med Chem. 2003 Apr;38(4):339-43. doi: 10.1016/s0223-5234(03)00050-3. Eur J Med Chem. 2003. PMID: 12750019

2

Design and synthesis of ethyl pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Andrews DM, Baker G, Bethell SS, Carey S, Chaignot H, Clarke B, Coomber B, Ellis M, Good A, Gray N, Hardy G, Jones P, Mills G, Robinson E. Slater MJ, et al. Among authors: andrews dm. Bioorg Med Chem Lett. 2002 Dec 2;12(23):3359-62. doi: 10.1016/s0960-894x(02)00789-8. Bioorg Med Chem Lett. 2002. PMID: 12419361

3

Pyrrolidine-5,5-trans-lactams. 1. Synthesis and incorporation into inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Carey SJ, Chaignot H, Coomber BA, Gray NM, Hind SL, Jones PS, Mills G, Robinson JE, Slater MJ. Andrews DM, et al. Org Lett. 2002 Dec 12;4(25):4475-8. doi: 10.1021/ol027013x. Org Lett. 2002. PMID: 12465916

4

Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents.

Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO. Andrews DM, et al. Org Lett. 2002 Dec 12;4(25):4479-82. doi: 10.1021/ol027014p. Org Lett. 2002. PMID: 12465917

5

Design and synthesis of spiro-cyclopentenyl and spiro-[1,3]-dithiolanyl substituted pyrrolidine-5,5-trans-lactams as inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Jones PS, Mills G, Hind SL, Slater MJ, Trivedi N, Wareing KJ. Andrews DM, et al. Bioorg Med Chem Lett. 2003 May 19;13(10):1657-60. doi: 10.1016/s0960-894x(03)00274-9. Bioorg Med Chem Lett. 2003. PMID: 12729635

6

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.

Slater MJ, Amphlett EM, Andrews DM, Bamborough P, Carey SJ, Johnson MR, Jones PS, Mills G, Parry NR, Somers DO, Stewart AJ, Skarzynski T. Slater MJ, et al. Among authors: andrews dm. Org Lett. 2003 Nov 27;5(24):4627-30. doi: 10.1021/ol035826v. Org Lett. 2003. PMID: 14627400

7

Pyrrolidine-5,5-trans-lactams. 5. Pharmacokinetic optimization of inhibitors of hepatitis C virus NS3/4A protease.

Andrews DM, Barnes MC, Dowle MD, Hind SL, Johnson MR, Jones PS, Mills G, Patikis A, Pateman TJ, Redfern TJ, Robinson JE, Slater MJ, Trivedi N. Andrews DM, et al. Org Lett. 2003 Nov 27;5(24):4631-4. doi: 10.1021/ol035827n. Org Lett. 2003. PMID: 14627401

8

Optimization of novel acyl pyrrolidine inhibitors of hepatitis C virus RNA-dependent RNA polymerase leading to a development candidate.

Slater MJ, Amphlett EM, Andrews DM, Bravi G, Burton G, Cheasty AG, Corfield JA, Ellis MR, Fenwick RH, Fernandes S, Guidetti R, Haigh D, Hartley CD, Howes PD, Jackson DL, Jarvest RL, Lovegrove VL, Medhurst KJ, Parry NR, Price H, Shah P, Singh OM, Stocker R, Thommes P, Wilkinson C, Wonacott A. Slater MJ, et al. Among authors: andrews dm. J Med Chem. 2007 Mar 8;50(5):897-900. doi: 10.1021/jm061207r. Epub 2007 Feb 2. J Med Chem. 2007. PMID: 17269759

9

Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain.

Andrews DM, Cherry PC, Humber DC, Jones PS, Keeling SP, Martin PF, Shaw CD, Swanson S. Andrews DM, et al. Eur J Med Chem. 1999 Jul-Aug;34(7-8):563-74. doi: 10.1016/s0223-5234(00)80026-4. Eur J Med Chem. 1999. PMID: 11278042

10

Design and campaign synthesis of piperidine- and thiazole-based histone deacetylase inhibitors.

Andrews DM, Stokes ES, Carr GR, Matusiak ZS, Roberts CA, Waring MJ, Brady MC, Chresta CM, East SJ. Andrews DM, et al. Bioorg Med Chem Lett. 2008 Apr 15;18(8):2580-4. doi: 10.1016/j.bmcl.2008.03.041. Epub 2008 Mar 16. Bioorg Med Chem Lett. 2008. PMID: 18378449

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