Sawada N - Search Results

1

Metabolism of 26,26,26,27,27,27-F6-1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats.

Sakaki T, Sawada N, Abe D, Komai K, Shiozawa S, Nonaka Y, Nakagawa K, Okano T, Ohta M, Inouye K. Sakaki T, et al. Among authors: sawada n. Biochem Pharmacol. 2003 Jun 15;65(12):1957-65. doi: 10.1016/s0006-2952(03)00190-4. Biochem Pharmacol. 2003. PMID: 12787875

2

Novel metabolism of 1 alpha,25-dihydroxyvitamin D3 with C24-C25 bond cleavage catalyzed by human CYP24A1.

Sawada N, Kusudo T, Sakaki T, Hatakeyama S, Hanada M, Abe D, Kamao M, Okano T, Ohta M, Inouye K. Sawada N, et al. Biochemistry. 2004 Apr 20;43(15):4530-7. doi: 10.1021/bi030207f. Biochemistry. 2004. PMID: 15078099

Our previous study revealed that human CYP24A1 catalyzes a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways that used both 25(OH)D(3) and 1alpha,25(OH)(2)D(3) as substrates, while rat CYP24A1 showed extreme predominance of the C-24 over C-23 hydroxyla …

Our previous study revealed that human CYP24A1 catalyzes a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways tha …

3

Conversion of vitamin D3 to 1alpha,25-dihydroxyvitamin D3 by Streptomyces griseolus cytochrome P450SU-1.

Sawada N, Sakaki T, Yoneda S, Kusudo T, Shinkyo R, Ohta M, Inouye K. Sawada N, et al. Biochem Biophys Res Commun. 2004 Jul 16;320(1):156-64. doi: 10.1016/j.bbrc.2004.05.140. Biochem Biophys Res Commun. 2004. PMID: 15207715

4

Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES.

Uchida E, Kagawa N, Sakaki T, Urushino N, Sawada N, Kamakura M, Ohta M, Kato S, Inouye K. Uchida E, et al. Among authors: sawada n. Biochem Biophys Res Commun. 2004 Oct 15;323(2):505-11. doi: 10.1016/j.bbrc.2004.08.110. Biochem Biophys Res Commun. 2004. PMID: 15369780

5

Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid.

Sakaki T, Sawada N, Nonaka Y, Ohyama Y, Inouye K. Sakaki T, et al. Among authors: sawada n. Eur J Biochem. 1999 May;262(1):43-8. doi: 10.1046/j.1432-1327.1999.00375.x. Eur J Biochem. 1999. PMID: 10231362 Free article.

6

Metabolism of vitamin D(3) by human CYP27A1.

Sawada N, Sakaki T, Ohta M, Inouye K. Sawada N, et al. Biochem Biophys Res Commun. 2000 Jul 14;273(3):977-84. doi: 10.1006/bbrc.2000.3050. Biochem Biophys Res Commun. 2000. PMID: 10891358

7

Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.

Sakaki T, Sawada N, Komai K, Shiozawa S, Yamada S, Yamamoto K, Ohyama Y, Inouye K. Sakaki T, et al. Among authors: sawada n. Eur J Biochem. 2000 Oct;267(20):6158-65. doi: 10.1046/j.1432-1327.2000.01680.x. Eur J Biochem. 2000. PMID: 11012668 Free article.

Human CYP24 demonstrated a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways towards both 25(OH)D3 and 1alpha,25(OH)2D3, whereas rat CYP24 showed almost no C-23 hydroxylation pathway [Sakaki, T. Sawada, N. Nonaka, Y. Ohyama, Y. & Inou …

Human CYP24 demonstrated a remarkable metabolism consisting of both C-23 and C-24 hydroxylation pathways towards both 25(OH)D3 and 1alpha,25 …

8

Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites.

Kamao M, Tatematsu S, Sawada N, Sakaki T, Hatakeyama S, Kubodera N, Okano T. Kamao M, et al. Among authors: sawada n. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):39-42. doi: 10.1016/j.jsbmb.2004.03.048. J Steroid Biochem Mol Biol. 2004. PMID: 15225744

9

Homology modeling of human 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5.

Yamamoto K, Masuno H, Sawada N, Sakaki T, Inouye K, Ishiguro M, Yamada S. Yamamoto K, et al. Among authors: sawada n. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):167-71. doi: 10.1016/j.jsbmb.2004.03.098. J Steroid Biochem Mol Biol. 2004. PMID: 15225767

10

Measurement and characterization of C-3 epimerization activity toward vitamin D3.

Kamao M, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Kubodera N, Reddy GS, Okano T. Kamao M, et al. Among authors: sawada n. Arch Biochem Biophys. 2005 Apr 1;436(1):196-205. doi: 10.1016/j.abb.2005.01.017. Arch Biochem Biophys. 2005. PMID: 15752725

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