Middleton MR - Search Results

1

Randomized phase II study of temozolomide given every 8 hours or daily with either interferon alfa-2b or thalidomide in metastatic malignant melanoma.

Danson S, Lorigan P, Arance A, Clamp A, Ranson M, Hodgetts J, Lomax L, Ashcroft L, Thatcher N, Middleton MR. Danson S, et al. Among authors: middleton mr. J Clin Oncol. 2003 Jul 1;21(13):2551-7. doi: 10.1200/JCO.2003.10.039. J Clin Oncol. 2003. PMID: 12829675 Clinical Trial.

2

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.

Middleton MR, Lunn JM, Morris C, Rustin G, Wedge SR, Brampton MH, Lind MJ, Lee SM, Newell DR, Bleehen NM, Newlands ES, Calvert AH, Margison GP, Thatcher N. Middleton MR, et al. Br J Cancer. 1998 Nov;78(9):1199-202. doi: 10.1038/bjc.1998.654. Br J Cancer. 1998. PMID: 9820180 Free PMC article. Clinical Trial.

3

Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma.

Middleton MR, Grob JJ, Aaronson N, Fierlbeck G, Tilgen W, Seiter S, Gore M, Aamdal S, Cebon J, Coates A, Dreno B, Henz M, Schadendorf D, Kapp A, Weiss J, Fraass U, Statkevich P, Muller M, Thatcher N. Middleton MR, et al. J Clin Oncol. 2000 Jan;18(1):158-66. doi: 10.1200/JCO.2000.18.1.158. J Clin Oncol. 2000. PMID: 10623706 Clinical Trial.

4

O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts.

Middleton MR, Kelly J, Thatcher N, Donnelly DJ, McElhinney RS, McMurry TB, McCormick JE, Margison GP. Middleton MR, et al. Int J Cancer. 2000 Jan 15;85(2):248-52. doi: 10.1002/(sici)1097-0215(20000115)85:2<248::aid-ijc16>3.0.co;2-v. Int J Cancer. 2000. PMID: 10629085

5

Four-hourly scheduling of temozolomide improves tumour growth delay but not therapeutic index in A375M melanoma xenografts.

Middleton MR, Kelly J, Goodger S, Thatcher N, Margison GP. Middleton MR, et al. Cancer Chemother Pharmacol. 2000;45(1):15-20. doi: 10.1007/PL00006737. Cancer Chemother Pharmacol. 2000. PMID: 10647496

6

A randomized phase III study comparing dacarbazine, BCNU, cisplatin and tamoxifen with dacarbazine and interferon in advanced melanoma.

Middleton MR, Lorigan P, Owen J, Ashcroft L, Lee SM, Harper P, Thatcher N. Middleton MR, et al. Br J Cancer. 2000 Mar;82(6):1158-62. doi: 10.1054/bjoc.1999.1056. Br J Cancer. 2000. PMID: 10735499 Free PMC article. Clinical Trial.

7

Post hoc economic analysis of temozolomide versus dacarbazine in the treatment of advanced metastatic melanoma.

Hillner BE, Agarwala S, Middleton MR. Hillner BE, et al. Among authors: middleton mr. J Clin Oncol. 2000 Apr;18(7):1474-80. doi: 10.1200/JCO.2000.18.7.1474. J Clin Oncol. 2000. PMID: 10735895 Clinical Trial.

8

Temozolomide for advanced, metastatic melanoma.

Cohen MH, Johnson JR, Middleton MR. Cohen MH, et al. Among authors: middleton mr. J Clin Oncol. 2000 May;18(10):2185. doi: 10.1200/JCO.2000.18.10.2185. J Clin Oncol. 2000. PMID: 10811684 No abstract available.

9

O6-methylguanine formation, repair protein depletion and clinical outcome with a 4 hr schedule of temozolomide in the treatment of advanced melanoma: results of a phase II study.

Middleton MR, Lee SM, Arance A, Wood M, Thatcher N, Margison GP. Middleton MR, et al. Int J Cancer. 2000 Nov 1;88(3):469-73. Int J Cancer. 2000. PMID: 11054678 Clinical Trial.

10

Adjuvant interferon in melanoma - a resurrection?

Middleton MR, Thatcher N. Middleton MR, et al. Br J Cancer. 2001 May 4;84(9):1141-2. doi: 10.1054/bjoc.2001.1798. Br J Cancer. 2001. PMID: 11336461 Free PMC article. No abstract available.

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