Wang H - Search Results

1

Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

Huai Q, Wang H, Sun Y, Kim HY, Liu Y, Ke H. Huai Q, et al. Among authors: wang h. Structure. 2003 Jul;11(7):865-73. doi: 10.1016/s0969-2126(03)00123-0. Structure. 2003. PMID: 12842049 Free article.

2

Crystal structure of DJ-1/RS and implication on familial Parkinson's disease.

Huai Q, Sun Y, Wang H, Chin LS, Li L, Robinson H, Ke H. Huai Q, et al. Among authors: wang h. FEBS Lett. 2003 Aug 14;549(1-3):171-5. doi: 10.1016/s0014-5793(03)00764-6. FEBS Lett. 2003. PMID: 12914946 Free article.

3

Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine binding.

Huai Q, Wang H, Zhang W, Colman RW, Robinson H, Ke H. Huai Q, et al. Among authors: wang h. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9624-9. doi: 10.1073/pnas.0401120101. Epub 2004 Jun 21. Proc Natl Acad Sci U S A. 2004. PMID: 15210993 Free PMC article.

4

Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.

Huai Q, Wang H, Liu Y, Kim HY, Toft D, Ke H. Huai Q, et al. Among authors: wang h. Structure. 2005 Apr;13(4):579-90. doi: 10.1016/j.str.2004.12.018. Structure. 2005. PMID: 15837196 Free article.

5

Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.

Wang H, Liu Y, Chen Y, Robinson H, Ke H. Wang H, et al. J Biol Chem. 2005 Sep 2;280(35):30949-55. doi: 10.1074/jbc.M504398200. Epub 2005 Jul 1. J Biol Chem. 2005. PMID: 15994308 Free article.

6

Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesterase.

Huai Q, Sun Y, Wang H, Macdonald D, Aspiotis R, Robinson H, Huang Z, Ke H. Huai Q, et al. Among authors: wang h. J Med Chem. 2006 Mar 23;49(6):1867-73. doi: 10.1021/jm051273d. J Med Chem. 2006. PMID: 16539372 Free PMC article.

7

Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development.

Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H. Wang H, et al. J Biol Chem. 2006 Jul 28;281(30):21469-21479. doi: 10.1074/jbc.M512527200. Epub 2006 May 30. J Biol Chem. 2006. PMID: 16735511 Free article.

8

Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity.

Ke H, Wang H. Ke H, et al. Among authors: wang h. Curr Top Med Chem. 2007;7(4):391-403. doi: 10.2174/156802607779941242. Curr Top Med Chem. 2007. PMID: 17305581 Review.

9

Structural insight into substrate specificity of phosphodiesterase 10.

Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Wang H, et al. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. doi: 10.1073/pnas.0700279104. Epub 2007 Mar 26. Proc Natl Acad Sci U S A. 2007. PMID: 17389385 Free PMC article.

10

The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10.

Wang H, Robinson H, Ke H. Wang H, et al. J Mol Biol. 2007 Aug 10;371(2):302-7. doi: 10.1016/j.jmb.2007.05.060. Epub 2007 May 26. J Mol Biol. 2007. PMID: 17582435 Free PMC article.

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