Takagi J - Search Results

1

Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface.

Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. Takagi J, et al. Nature. 2003 Aug 21;424(6951):969-74. doi: 10.1038/nature01873. Nature. 2003. PMID: 12931195

2

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain.

Huang C, Zang Q, Takagi J, Springer TA. Huang C, et al. Among authors: takagi j. J Biol Chem. 2000 Jul 14;275(28):21514-24. doi: 10.1074/jbc.M002286200. J Biol Chem. 2000. PMID: 10779511 Free article.

3

The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3.

Zang Q, Lu C, Huang C, Takagi J, Springer TA. Zang Q, et al. Among authors: takagi j. J Biol Chem. 2000 Jul 21;275(29):22202-12. doi: 10.1074/jbc.M002883200. J Biol Chem. 2000. PMID: 10781608 Free article.

4

Computational design of an integrin I domain stabilized in the open high affinity conformation.

Shimaoka M, Shifman JM, Jing H, Takagi J, Mayo SL, Springer TA. Shimaoka M, et al. Among authors: takagi j. Nat Struct Biol. 2000 Aug;7(8):674-8. doi: 10.1038/77978. Nat Struct Biol. 2000. PMID: 10932253

5

A novel Ca2+ binding beta hairpin loop better resembles integrin sequence motifs than the EF hand.

Springer TA, Jing H, Takagi J. Springer TA, et al. Among authors: takagi j. Cell. 2000 Aug 4;102(3):275-7. doi: 10.1016/s0092-8674(00)00033-7. Cell. 2000. PMID: 10975518 Free article. No abstract available.

6

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

Lu C, Shimaoka M, Ferzly M, Oxvig C, Takagi J, Springer TA. Lu C, et al. Among authors: takagi j. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2387-92. doi: 10.1073/pnas.041606398. Proc Natl Acad Sci U S A. 2001. PMID: 11226249 Free PMC article.

7

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.

Lu C, Shimaoka M, Zang Q, Takagi J, Springer TA. Lu C, et al. Among authors: takagi j. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2393-8. doi: 10.1073/pnas.041618598. Proc Natl Acad Sci U S A. 2001. PMID: 11226250 Free PMC article.

8

Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state.

Lu C, Takagi J, Springer TA. Lu C, et al. Among authors: takagi j. J Biol Chem. 2001 May 4;276(18):14642-8. doi: 10.1074/jbc.M100600200. Epub 2001 Jan 30. J Biol Chem. 2001. PMID: 11279101 Free article.

9

Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation.

Lu C, Ferzly M, Takagi J, Springer TA. Lu C, et al. Among authors: takagi j. J Immunol. 2001 May 1;166(9):5629-37. doi: 10.4049/jimmunol.166.9.5629. J Immunol. 2001. PMID: 11313403

10

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.

Takagi J, Erickson HP, Springer TA. Takagi J, et al. Nat Struct Biol. 2001 May;8(5):412-6. doi: 10.1038/87569. Nat Struct Biol. 2001. PMID: 11323715

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