Savino R - Search Results

1

Interleukin 6 is important for survival after partial hepatectomy in mice.

Blindenbacher A, Wang X, Langer I, Savino R, Terracciano L, Heim MH. Blindenbacher A, et al. Among authors: savino r. Hepatology. 2003 Sep;38(3):674-82. doi: 10.1053/jhep.2003.50378. Hepatology. 2003. PMID: 12939594

2

In vivo neutralization of human IL-6 (hIL-6) achieved by immunization of hIL-6-transgenic mice with a hIL-6 receptor antagonist.

De Benedetti F, Pignatti P, Vivarelli M, Meazza C, Ciliberto G, Savino R, Martini A. De Benedetti F, et al. Among authors: savino r. J Immunol. 2001 Apr 1;166(7):4334-40. doi: 10.4049/jimmunol.166.7.4334. J Immunol. 2001. PMID: 11254686

3

Coexpression of IL-6 and soluble IL-6R causes nodular regenerative hyperplasia and adenomas of the liver.

Maione D, Di Carlo E, Li W, Musiani P, Modesti A, Peters M, Rose-John S, Della Rocca C, Tripodi M, Lazzaro D, Taub R, Savino R, Ciliberto G. Maione D, et al. Among authors: savino r. EMBO J. 1998 Oct 1;17(19):5588-97. doi: 10.1093/emboj/17.19.5588. EMBO J. 1998. PMID: 9755159 Free PMC article.

4

Synergistic induction of growth arrest and apoptosis of human myeloma cells by the IL-6 super-antagonist Sant7 and Dexamethasone.

Tassone P, Forciniti S, Galea E, Savino R, Turco MC, Iacopino P, Tagliaferri P, Morrone G, Ciliberto G, Venuta S. Tassone P, et al. Among authors: savino r. Cell Death Differ. 2000 Mar;7(3):327-8. doi: 10.1038/sj.cdd.4400635. Cell Death Differ. 2000. PMID: 10866493 No abstract available.

5

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.

Savino R, Lahm A, Salvati AL, Ciapponi L, Sporeno E, Altamura S, Paonessa G, Toniatti C, Ciliberto G. Savino R, et al. EMBO J. 1994 Mar 15;13(6):1357-67. doi: 10.1002/j.1460-2075.1994.tb06389.x. EMBO J. 1994. PMID: 7511100 Free PMC article.

6

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling.

Paonessa G, Graziani R, De Serio A, Savino R, Ciapponi L, Lahm A, Salvati AL, Toniatti C, Ciliberto G. Paonessa G, et al. Among authors: savino r. EMBO J. 1995 May 1;14(9):1942-51. doi: 10.1002/j.1460-2075.1995.tb07186.x. EMBO J. 1995. PMID: 7744001 Free PMC article.

7

Rational design of a receptor super-antagonist of human interleukin-6.

Savino R, Ciapponi L, Lahm A, Demartis A, Cabibbo A, Toniatti C, Delmastro P, Altamura S, Ciliberto G. Savino R, et al. EMBO J. 1994 Dec 15;13(24):5863-70. doi: 10.1002/j.1460-2075.1994.tb06931.x. EMBO J. 1994. PMID: 7813426 Free PMC article.

8

A fast and sensitive colorimetric assay for IL-6 in hepatoma cells based on the production of a secreted form of alkaline phosphatase (SEAP).

Gregory B, Savino R, Ciliberto G. Gregory B, et al. Among authors: savino r. J Immunol Methods. 1994 Mar 29;170(1):47-56. doi: 10.1016/0022-1759(94)90244-5. J Immunol Methods. 1994. PMID: 8157987

9

Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist.

Ciapponi L, Maione D, Scoumanne A, Costa P, Hansen MB, Svenson M, Bendtzen K, Alonzi T, Paonessa G, Cortese R, Ciliberto G, Savino R. Ciapponi L, et al. Among authors: savino r. Nat Biotechnol. 1997 Oct;15(10):997-1001. doi: 10.1038/nbt1097-997. Nat Biotechnol. 1997. PMID: 9335053

10

Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death.

Demartis A, Bernassola F, Savino R, Melino G, Ciliberto G. Demartis A, et al. Among authors: savino r. Cancer Res. 1996 Sep 15;56(18):4213-8. Cancer Res. 1996. PMID: 8797594

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