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Cumulative mutagenesis of the basic residues in the 201-218 region of insulin-like growth factor (IGF)-binding protein-5 results in progressive loss of both IGF-I binding and inhibition of IGF-I biological action.
Allan GJ, Tonner E, Szymanowska M, Shand JH, Kelly SM, Phillips K, Clegg RA, Gow IF, Beattie J, Flint DJ. Allan GJ, et al. Among authors: szymanowska m. Endocrinology. 2006 Jan;147(1):338-49. doi: 10.1210/en.2005-0582. Epub 2005 Sep 29. Endocrinology. 2006. PMID: 16195401 Free article.
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