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Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.
Lu D, Zhang H, Ludwig D, Persaud A, Jimenez X, Burtrum D, Balderes P, Liu M, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: balderes p. J Biol Chem. 2004 Jan 23;279(4):2856-65. doi: 10.1074/jbc.M310132200. Epub 2003 Oct 23. J Biol Chem. 2004. PMID: 14576153 Free article.
A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.
Lu D, Zhang H, Koo H, Tonra J, Balderes P, Prewett M, Corcoran E, Mangalampalli V, Bassi R, Anselma D, Patel D, Kang X, Ludwig DL, Hicklin DJ, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: balderes p. J Biol Chem. 2005 May 20;280(20):19665-72. doi: 10.1074/jbc.M500815200. Epub 2005 Mar 9. J Biol Chem. 2005. PMID: 15757893 Free article.
Targeting the platelet-derived growth factor receptor alpha with a neutralizing human monoclonal antibody inhibits the growth of tumor xenografts: implications as a potential therapeutic target.
Loizos N, Xu Y, Huber J, Liu M, Lu D, Finnerty B, Rolser R, Malikzay A, Persaud A, Corcoran E, Deevi DS, Balderes P, Bassi R, Jimenez X, Joynes CJ, Mangalampalli VR, Steiner P, Tonra JR, Wu Y, Pereira DS, Zhu Z, Ludwig DL, Hicklin DJ, Bohlen P, Witte L, Kussie P. Loizos N, et al. Among authors: balderes p. Mol Cancer Ther. 2005 Mar;4(3):369-79. doi: 10.1158/1535-7163.MCT-04-0114. Mol Cancer Ther. 2005. PMID: 15767546
An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody.
Shen J, Vil MD, Zhang H, Tonra JR, Rong LL, Damoci C, Prewett M, Deevi DS, Kearney J, Surguladze D, Jimenez X, Iacolina M, Bassi R, Zhou K, Balderes P, Mangalampalli VR, Loizos N, Ludwig DL, Zhu Z. Shen J, et al. Among authors: balderes p. Biochem Biophys Res Commun. 2007 Jun 15;357(4):1142-7. doi: 10.1016/j.bbrc.2007.04.075. Epub 2007 Apr 19. Biochem Biophys Res Commun. 2007. PMID: 17462601
Development of a fully human anti-PDGFRbeta antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody.
Shen J, Vil MD, Prewett M, Damoci C, Zhang H, Li H, Jimenez X, Deevi DS, Iacolina M, Kayas A, Bassi R, Persaud K, Rohoza-Asandi A, Balderes P, Loizos N, Ludwig DL, Tonra J, Witte L, Zhu Z. Shen J, et al. Among authors: balderes p. Neoplasia. 2009 Jun;11(6):594-604. doi: 10.1593/neo.09278. Neoplasia. 2009. PMID: 19484148 Free PMC article.
28 results