Bohlen P - Search Results

1

Di-diabody: a novel tetravalent bispecific antibody molecule by design.

Lu D, Jimenez X, Zhang H, Atkins A, Brennan L, Balderes P, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. J Immunol Methods. 2003 Aug;279(1-2):219-32. doi: 10.1016/s0022-1759(03)00251-5. J Immunol Methods. 2003. PMID: 12969563

2

Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy.

Lu D, Jimenez X, Zhang H, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. Int J Cancer. 2002 Jan 20;97(3):393-9. doi: 10.1002/ijc.1634. Int J Cancer. 2002. PMID: 11774295

3

Fab-scFv fusion protein: an efficient approach to production of bispecific antibody fragments.

Lu D, Jimenez X, Zhang H, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. J Immunol Methods. 2002 Sep 15;267(2):213-26. doi: 10.1016/s0022-1759(02)00148-5. J Immunol Methods. 2002. PMID: 12165442

4

Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity.

Lu D, Shen J, Vil MD, Zhang H, Jimenez X, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. J Biol Chem. 2003 Oct 31;278(44):43496-507. doi: 10.1074/jbc.M307742200. Epub 2003 Aug 12. J Biol Chem. 2003. PMID: 12917408 Free article.

5

Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody.

Lu D, Zhang H, Ludwig D, Persaud A, Jimenez X, Burtrum D, Balderes P, Liu M, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. J Biol Chem. 2004 Jan 23;279(4):2856-65. doi: 10.1074/jbc.M310132200. Epub 2003 Oct 23. J Biol Chem. 2004. PMID: 14576153 Free article.

6

Inhibition of both the autocrine and the paracrine growth of human leukemia with a fully human antibody directed against vascular endothelial growth factor receptor 2.

Zhang H, Li Y, Li H, Bassi R, Jimenez X, Witte L, Bohlen P, Hicklin D, Zhu Z. Zhang H, et al. Among authors: bohlen p. Leuk Lymphoma. 2004 Sep;45(9):1887-97. doi: 10.1080/10428190410001712225. Leuk Lymphoma. 2004. PMID: 15223651

7

A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity.

Lu D, Zhang H, Koo H, Tonra J, Balderes P, Prewett M, Corcoran E, Mangalampalli V, Bassi R, Anselma D, Patel D, Kang X, Ludwig DL, Hicklin DJ, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. J Biol Chem. 2005 May 20;280(20):19665-72. doi: 10.1074/jbc.M500815200. Epub 2005 Mar 9. J Biol Chem. 2005. PMID: 15757893 Free article.

8

Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF kinase receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor.

Lu D, Jimenez X, Zhang H, Wu Y, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. Cancer Res. 2001 Oct 1;61(19):7002-8. Cancer Res. 2001. PMID: 11585724

9

Acquired antagonistic activity of a bispecific diabody directed against two different epitopes on vascular endothelial growth factor receptor 2.

Lu D, Kotanides H, Jimenez X, Zhou Q, Persaud K, Bohlen P, Witte L, Zhu Z. Lu D, et al. Among authors: bohlen p. J Immunol Methods. 1999 Nov 19;230(1-2):159-71. doi: 10.1016/s0022-1759(99)00135-0. J Immunol Methods. 1999. PMID: 10594363

10

Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics.

Zhu Z, Bohlen P, Witte L. Zhu Z, et al. Among authors: bohlen p. Curr Cancer Drug Targets. 2002 Jun;2(2):135-56. doi: 10.2174/1568009023333881. Curr Cancer Drug Targets. 2002. PMID: 12188915 Review.

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