Vicario PP - Search Results

1

Synthesis and hypoglycemic activity of substituted 8-(1-piperazinyl)imidazo[1,2-a]pyrazines.

Meurer LC, Tolman RL, Chapin EW, Saperstein R, Vicario PP, Zrada MM, MacCoss M. Meurer LC, et al. Among authors: vicario pp. J Med Chem. 1992 Oct 16;35(21):3845-57. doi: 10.1021/jm00099a012. J Med Chem. 1992. PMID: 1359141

2

Novel, orally bioavailable gamma-aminoamide CC chemokine receptor 2 (CCR2) antagonists.

Pasternak A, Marino D, Vicario PP, Ayala JM, Cascierri MA, Parsons W, Mills SG, Maccoss M, Yang L. Pasternak A, et al. Among authors: vicario pp. J Med Chem. 2006 Aug 10;49(16):4801-4. doi: 10.1021/jm060439n. J Med Chem. 2006. PMID: 16884289

3

Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists.

Yang L, Butora G, Jiao RX, Pasternak A, Zhou C, Parsons WH, Mills SG, Vicario PP, Ayala JM, Cascieri MA, MacCoss M. Yang L, et al. Among authors: vicario pp. J Med Chem. 2007 May 31;50(11):2609-11. doi: 10.1021/jm070166b. Epub 2007 Apr 27. J Med Chem. 2007. PMID: 17461566

4

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

Kothandaraman S, Donnely KL, Butora G, Jiao R, Pasternak A, Morriello GJ, Goble SD, Zhou C, Mills SG, Maccoss M, Vicario PP, Ayala JM, Demartino JA, Struthers M, Cascieri MA, Yang L. Kothandaraman S, et al. Among authors: vicario pp. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1830-4. doi: 10.1016/j.bmcl.2008.12.050. Epub 2008 Dec 24. Bioorg Med Chem Lett. 2009. PMID: 19237282

5

Discovery of 3,5-bis(trifluoromethyl)benzyl L-arylglycinamide based potent CCR2 antagonists.

Yang L, Zhou C, Guo L, Morriello G, Butora G, Pasternak A, Parsons WH, Mills SG, MacCoss M, Vicario PP, Zweerink H, Ayala JM, Goyal S, Hanlon WA, Cascieri MA, Springer MS. Yang L, et al. Among authors: vicario pp. Bioorg Med Chem Lett. 2006 Jul 15;16(14):3735-9. doi: 10.1016/j.bmcl.2006.04.045. Epub 2006 May 15. Bioorg Med Chem Lett. 2006. PMID: 16698264

6

4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties.

Butora G, Morriello GJ, Kothandaraman S, Guiadeen D, Pasternak A, Parsons WH, MacCoss M, Vicario PP, Cascieri MA, Yang L. Butora G, et al. Among authors: vicario pp. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4715-22. doi: 10.1016/j.bmcl.2006.07.011. Epub 2006 Jul 25. Bioorg Med Chem Lett. 2006. PMID: 16870431

7

Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.

Zhou C, Guo L, Parsons WH, Mills SG, MacCoss M, Vicario PP, Zweerink H, Cascieri MA, Springer MS, Yang L. Zhou C, et al. Among authors: vicario pp. Bioorg Med Chem Lett. 2007 Jan 15;17(2):309-14. doi: 10.1016/j.bmcl.2006.10.059. Epub 2006 Oct 25. Bioorg Med Chem Lett. 2007. PMID: 17092717

8

The effect of ponalrestat on sorbitol levels in the lens of obese and diabetic mice.

Vicario PP, Slater EE, Saperstein R. Vicario PP, et al. Biochem Int. 1989 Sep;19(3):553-61. Biochem Int. 1989. PMID: 2510726

9

Impaired insulin-like growth factor I-mediated stimulation of glucose incorporation into glycogen in vivo in the ob/ob mouse.

Cascieri MA, Slater EE, Vicario PP, Green BG, Bayne ML, Saperstein R. Cascieri MA, et al. Among authors: vicario pp. Diabetologia. 1989 Jun;32(6):342-7. doi: 10.1007/BF00277256. Diabetologia. 1989. PMID: 2547681

10

Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells.

Saperstein R, Vicario PP, Strout HV, Brady E, Slater EE, Greenlee WJ, Ondeyka DL, Patchett AA, Hangauer DG. Saperstein R, et al. Among authors: vicario pp. Biochemistry. 1989 Jun 27;28(13):5694-701. doi: 10.1021/bi00439a053. Biochemistry. 1989. PMID: 2550060

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