Schorn TW - Search Results

1

Highly potent, orally active diester macrocyclic human renin inhibitors.

Weber AE, Steiner MG, Krieter PA, Colletti AE, Tata JR, Halgren TA, Ball RG, Doyle JJ, Schorn TW, Stearns RA, et al. Weber AE, et al. Among authors: schorn tw. J Med Chem. 1992 Oct 16;35(21):3755-73. doi: 10.1021/jm00099a004. J Med Chem. 1992. PMID: 1433190

2

Synthesis and use of 3-amino-4-phenyl-2-piperidones and 4-amino-2-benzazepin-3-ones as conformationally restricted phenylalanine isosteres in renin inhibitors.

de Laszlo SE, Bush BL, Doyle JJ, Greenlee WJ, Hangauer DG, Halgren TA, Lynch RJ, Schorn TW, Siegl PK. de Laszlo SE, et al. Among authors: schorn tw. J Med Chem. 1992 Mar 6;35(5):833-46. doi: 10.1021/jm00083a006. J Med Chem. 1992. PMID: 1548675

3

Renin inhibitors containing conformationally restricted P1-P1' dipeptide mimetics.

Williams PD, Perlow DS, Payne LS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: schorn tw. J Med Chem. 1991 Mar;34(3):887-900. doi: 10.1021/jm00107a004. J Med Chem. 1991. PMID: 2002469

4

Inhibitors of human renin with C-termini derived from amides and esters of alpha-mercaptoalkanoic acids.

Ashton WT, Cantone CL, Tolman RL, Greenlee WJ, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: schorn tw. J Med Chem. 1992 Jul 24;35(15):2772-81. doi: 10.1021/jm00093a009. J Med Chem. 1992. PMID: 1495010

5

Renin inhibitors containing C-termini derived from mercaptoheterocycles.

Ashton WT, Cantone CL, Meurer LC, Tolman RL, Greenlee WJ, Patchett AA, Lynch RJ, Schorn TW, Strouse JF, Siegl PK. Ashton WT, et al. Among authors: schorn tw. J Med Chem. 1992 May 29;35(11):2103-12. doi: 10.1021/jm00089a023. J Med Chem. 1992. PMID: 1597860

6

Design of renin inhibitors containing conformationally restricted mimetics of the P1-P1' and P1 through P2' sites.

Williams PD, Payne LS, Perlow DS, Holloway MK, Siegl PK, Schorn TW, Lynch RJ, Doyle JJ, Strouse JF, Vlasuk GP, et al. Williams PD, et al. Among authors: schorn tw. Adv Exp Med Biol. 1991;306:325-34. doi: 10.1007/978-1-4684-6012-4_38. Adv Exp Med Biol. 1991. PMID: 1812722 No abstract available.

7

Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists.

Mantlo NB, Chakravarty PK, Ondeyka DL, Siegl PK, Chang RS, Lotti VJ, Faust KA, Chen TB, Schorn TW, Sweet CS, et al. Mantlo NB, et al. Among authors: schorn tw. J Med Chem. 1991 Sep;34(9):2919-22. doi: 10.1021/jm00113a035. J Med Chem. 1991. PMID: 1895308 No abstract available.

8

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

Barrow JC, Nantermet PG, Selnick HG, Glass KL, Rittle KE, Gilbert KF, Steele TG, Homnick CF, Freidinger RM, Ransom RW, Kling P, Reiss D, Broten TP, Schorn TW, Chang RS, O'Malley SS, Olah TV, Ellis JD, Barrish A, Kassahun K, Leppert P, Nagarathnam D, Forray C. Barrow JC, et al. Among authors: schorn tw. J Med Chem. 2000 Jul 13;43(14):2703-18. doi: 10.1021/jm990612y. J Med Chem. 2000. PMID: 10893308

9

Acute hypotensive responses to peptide inhibitors of renin in conscious monkeys: an effect on blood pressure independent of plasma renin inhibition.

Schaffer LW, Schorn TW, Winquist RJ, Strouse JF, Payne L, Chakravarty PK, de Laszlo SE, tenBroeke J, Veber DF, Greenlee WJ, et al. Schaffer LW, et al. Among authors: schorn tw. J Hypertens. 1990 Mar;8(3):251-9. J Hypertens. 1990. PMID: 2159506

10

Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analogue inhibitors containing a novel analogue of statine.

Boger J, Payne LS, Perlow DS, Lohr NS, Poe M, Blaine EH, Ulm EH, Schorn TW, LaMont BI, Lin TY, et al. Boger J, et al. Among authors: schorn tw. J Med Chem. 1985 Dec;28(12):1779-90. doi: 10.1021/jm00150a007. J Med Chem. 1985. PMID: 3906131

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