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The lipoprotein receptor-related protein-1 (LRP) adapter protein GULP mediates trafficking of the LRP ligand prosaposin, leading to sphingolipid and free cholesterol accumulation in late endosomes and impaired efflux.
Kiss RS, Ma Z, Nakada-Tsukui K, Brugnera E, Vassiliou G, McBride HM, Ravichandran KS, Marcel YL. Kiss RS, et al. J Biol Chem. 2006 Apr 28;281(17):12081-92. doi: 10.1074/jbc.M600621200. Epub 2006 Feb 22. J Biol Chem. 2006. PMID: 16497666 Free article.
58 results