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Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations.
Fikkert V, Van Maele B, Vercammen J, Hantson A, Van Remoortel B, Michiels M, Gurnari C, Pannecouque C, De Maeyer M, Engelborghs Y, De Clercq E, Debyser Z, Witvrouw M. Fikkert V, et al. Among authors: engelborghs y. J Virol. 2003 Nov;77(21):11459-70. doi: 10.1128/jvi.77.21.11459-11470.2003. J Virol. 2003. PMID: 14557631 Free PMC article.
Novel inhibitors of HIV-1 integration.
Witvrouw M, Van Maele B, Vercammen J, Hantson A, Engelborghs Y, De Clercq E, Pannecouque C, Debyser Z. Witvrouw M, et al. Among authors: engelborghs y. Curr Drug Metab. 2004 Aug;5(4):291-304. doi: 10.2174/1389200043335487. Curr Drug Metab. 2004. PMID: 15320701 Review.
Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.
Hombrouck A, Hantson A, van Remoortel B, Michiels M, Vercammen J, Rhodes D, Tetz V, Engelborghs Y, Christ F, Debyser Z, Witvrouw M. Hombrouck A, et al. Among authors: engelborghs y. J Antimicrob Chemother. 2007 Jun;59(6):1084-95. doi: 10.1093/jac/dkm101. Epub 2007 Apr 30. J Antimicrob Chemother. 2007. PMID: 17470918
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.
Busschots K, Vercammen J, Emiliani S, Benarous R, Engelborghs Y, Christ F, Debyser Z. Busschots K, et al. Among authors: engelborghs y. J Biol Chem. 2005 May 6;280(18):17841-7. doi: 10.1074/jbc.M411681200. Epub 2005 Mar 4. J Biol Chem. 2005. PMID: 15749713 Free article.
We have previously shown that the p75 isoform of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency virus (HIV)-1 integrase (IN) and is essential for nuclear targeting of this protein in human cells (Cherep …
We have previously shown that the p75 isoform of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF) interacts ti …
171 results