Vazquez F - Search Results

1

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ. Zhang H, et al. Among authors: vazquez f. J Clin Invest. 2003 Oct;112(8):1223-33. doi: 10.1172/JCI17222. J Clin Invest. 2003. PMID: 14561707 Free PMC article.

2

TSC2 regulates VEGF through mTOR-dependent and -independent pathways.

Brugarolas JB, Vazquez F, Reddy A, Sellers WR, Kaelin WG Jr. Brugarolas JB, et al. Among authors: vazquez f. Cancer Cell. 2003 Aug;4(2):147-58. doi: 10.1016/s1535-6108(03)00187-9. Cancer Cell. 2003. PMID: 12957289 Free article.

3

H3K27me3-mediated PGC1α gene silencing promotes melanoma invasion through WNT5A and YAP.

Luo C, Balsa E, Perry EA, Liang J, Tavares CD, Vazquez F, Widlund HR, Puigserver P. Luo C, et al. Among authors: vazquez f. J Clin Invest. 2020 Feb 3;130(2):853-862. doi: 10.1172/JCI130038. J Clin Invest. 2020. PMID: 31929186 Free PMC article.

4

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR. Ramaswamy S, et al. Among authors: vazquez f. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5. doi: 10.1073/pnas.96.5.2110. Proc Natl Acad Sci U S A. 1999. PMID: 10051603 Free PMC article.

5

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling.

Vazquez F, Sellers WR. Vazquez F, et al. Biochim Biophys Acta. 2000 Feb 14;1470(1):M21-35. doi: 10.1016/s0304-419x(99)00032-3. Biochim Biophys Acta. 2000. PMID: 10656987 Review. No abstract available.

6

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M, Sellers WR. Nakamura N, et al. Among authors: vazquez f. Mol Cell Biol. 2000 Dec;20(23):8969-82. doi: 10.1128/MCB.20.23.8969-8982.2000. Mol Cell Biol. 2000. PMID: 11073996 Free PMC article.

7

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex.

Vazquez F, Grossman SR, Takahashi Y, Rokas MV, Nakamura N, Sellers WR. Vazquez F, et al. J Biol Chem. 2001 Dec 28;276(52):48627-30. doi: 10.1074/jbc.C100556200. Epub 2001 Nov 13. J Biol Chem. 2001. PMID: 11707428 Free article.

8

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene.

Torres-Arzayus MI, Font de Mora J, Yuan J, Vazquez F, Bronson R, Rue M, Sellers WR, Brown M. Torres-Arzayus MI, et al. Among authors: vazquez f. Cancer Cell. 2004 Sep;6(3):263-74. doi: 10.1016/j.ccr.2004.06.027. Cancer Cell. 2004. PMID: 15380517 Free article.

9

mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex.

Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. Cunningham JT, et al. Among authors: vazquez f. Nature. 2007 Nov 29;450(7170):736-40. doi: 10.1038/nature06322. Nature. 2007. PMID: 18046414

10

CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.

Chen L, Alexe G, Dharia NV, Ross L, Iniguez AB, Conway AS, Wang EJ, Veschi V, Lam N, Qi J, Gustafson WC, Nasholm N, Vazquez F, Weir BA, Cowley GS, Ali LD, Pantel S, Jiang G, Harrington WF, Lee Y, Goodale A, Lubonja R, Krill-Burger JM, Meyers RM, Tsherniak A, Root DE, Bradner JE, Golub TR, Roberts CW, Hahn WC, Weiss WA, Thiele CJ, Stegmaier K. Chen L, et al. Among authors: vazquez f. J Clin Invest. 2018 Jan 2;128(1):446-462. doi: 10.1172/JCI90793. Epub 2017 Dec 4. J Clin Invest. 2018. PMID: 29202477 Free PMC article.

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