Zhang H - Search Results

1

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ. Zhang H, et al. J Clin Invest. 2003 Oct;112(8):1223-33. doi: 10.1172/JCI17222. J Clin Invest. 2003. PMID: 14561707 Free PMC article.

2

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.

Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, Onda H. Kwiatkowski DJ, et al. Among authors: zhang h. Hum Mol Genet. 2002 Mar 1;11(5):525-34. doi: 10.1093/hmg/11.5.525. Hum Mol Genet. 2002. PMID: 11875047

3

Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway.

Onda H, Crino PB, Zhang H, Murphey RD, Rastelli L, Gould Rothberg BE, Kwiatkowski DJ. Onda H, et al. Among authors: zhang h. Mol Cell Neurosci. 2002 Dec;21(4):561-74. doi: 10.1006/mcne.2002.1184. Mol Cell Neurosci. 2002. PMID: 12504590

4

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma.

El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ. El-Hashemite N, et al. Among authors: zhang h. Lancet. 2003 Apr 19;361(9366):1348-9. doi: 10.1016/S0140-6736(03)13044-9. Lancet. 2003. PMID: 12711473

5

Loss of Tsc1 or Tsc2 induces vascular endothelial growth factor production through mammalian target of rapamycin.

El-Hashemite N, Walker V, Zhang H, Kwiatkowski DJ. El-Hashemite N, et al. Among authors: zhang h. Cancer Res. 2003 Sep 1;63(17):5173-7. Cancer Res. 2003. PMID: 14500340

6

Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation.

Chan JA, Zhang H, Roberts PS, Jozwiak S, Wieslawa G, Lewin-Kowalik J, Kotulska K, Kwiatkowski DJ. Chan JA, et al. Among authors: zhang h. J Neuropathol Exp Neurol. 2004 Dec;63(12):1236-42. doi: 10.1093/jnen/63.12.1236. J Neuropathol Exp Neurol. 2004. PMID: 15624760

7

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR.

Zhang H, Bajraszewski N, Wu E, Wang H, Moseman AP, Dabora SL, Griffin JD, Kwiatkowski DJ. Zhang H, et al. J Clin Invest. 2007 Mar;117(3):730-8. doi: 10.1172/JCI28984. Epub 2007 Feb 8. J Clin Invest. 2007. PMID: 17290308 Free PMC article.

8

Estrogen-induced smooth muscle cell growth is regulated by tuberin and associated with altered activation of platelet-derived growth factor receptor-beta and ERK-1/2.

Finlay GA, York B, Karas RH, Fanburg BL, Zhang H, Kwiatkowski DJ, Noonan DJ. Finlay GA, et al. Among authors: zhang h. J Biol Chem. 2004 May 28;279(22):23114-22. doi: 10.1074/jbc.M401912200. Epub 2004 Mar 23. J Biol Chem. 2004. PMID: 15039427 Free article.

9

Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment.

El-Hashemite N, Zhang H, Walker V, Hoffmeister KM, Kwiatkowski DJ. El-Hashemite N, et al. Among authors: zhang h. Cancer Res. 2004 May 15;64(10):3436-43. doi: 10.1158/0008-5472.CAN-03-3609. Cancer Res. 2004. PMID: 15150095

10

Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models.

Lee L, Sudentas P, Donohue B, Asrican K, Worku A, Walker V, Sun Y, Schmidt K, Albert MS, El-Hashemite N, Lader AS, Onda H, Zhang H, Kwiatkowski DJ, Dabora SL. Lee L, et al. Among authors: zhang h. Genes Chromosomes Cancer. 2005 Mar;42(3):213-27. doi: 10.1002/gcc.20118. Genes Chromosomes Cancer. 2005. PMID: 15578690

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