Mehlig M - Search Results

1

Tailoring structure-function and pharmacokinetic properties of single-chain Fv proteins by site-specific PEGylation.

Yang K, Basu A, Wang M, Chintala R, Hsieh MC, Liu S, Hua J, Zhang Z, Zhou J, Li M, Phyu H, Petti G, Mendez M, Janjua H, Peng P, Longley C, Borowski V, Mehlig M, Filpula D. Yang K, et al. Among authors: mehlig m. Protein Eng. 2003 Oct;16(10):761-70. doi: 10.1093/protein/gzg093. Protein Eng. 2003. PMID: 14600206

2

Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by site-selective mono-PEGylation.

Basu A, Yang K, Wang M, Liu S, Chintala R, Palm T, Zhao H, Peng P, Wu D, Zhang Z, Hua J, Hsieh MC, Zhou J, Petti G, Li X, Janjua A, Mendez M, Liu J, Longley C, Zhang Z, Mehlig M, Borowski V, Viswanathan M, Filpula D. Basu A, et al. Among authors: mehlig m. Bioconjug Chem. 2006 May-Jun;17(3):618-30. doi: 10.1021/bc050322y. Bioconjug Chem. 2006. PMID: 16704199

3

Engineering an arginine catabolizing bioconjugate: Biochemical and pharmacological characterization of PEGylated derivatives of arginine deiminase from Mycoplasma arthritidis.

Wang M, Basu A, Palm T, Hua J, Youngster S, Hwang L, Liu HC, Li X, Peng P, Zhang Y, Zhao H, Zhang Z, Longley C, Mehlig M, Borowski V, Sai P, Viswanathan M, Jang E, Petti G, Liu S, Yang K, Filpula D. Wang M, et al. Among authors: mehlig m. Bioconjug Chem. 2006 Nov-Dec;17(6):1447-59. doi: 10.1021/bc060198y. Bioconjug Chem. 2006. PMID: 17105223

4

Delivery of G3139 using releasable PEG-linkers: impact on pharmacokinetic profile and anti-tumor efficacy.

Zhao H, Peng P, Longley C, Zhang Y, Borowski V, Mehlig M, Reddy P, Xia J, Borchard G, Lipman J, Benimetskaya L, Stein CA. Zhao H, et al. Among authors: mehlig m. J Control Release. 2007 Jun 4;119(2):143-52. doi: 10.1016/j.jconrel.2006.12.021. Epub 2006 Dec 29. J Control Release. 2007. PMID: 17397960

5

Antitumor activity of poly(ethylene glycol)-camptothecin conjugate: the inhibition of tumor growth in vivo.

Yu D, Peng P, Dharap SS, Wang Y, Mehlig M, Chandna P, Zhao H, Filpula D, Yang K, Borowski V, Borchard G, Zhang Z, Minko T. Yu D, et al. Among authors: mehlig m. J Control Release. 2005 Dec 10;110(1):90-102. doi: 10.1016/j.jconrel.2005.09.050. Epub 2005 Nov 4. J Control Release. 2005. PMID: 16271793

6

Novel delivery of SN38 markedly inhibits tumor growth in xenografts, including a camptothecin-11-refractory model.

Sapra P, Zhao H, Mehlig M, Malaby J, Kraft P, Longley C, Greenberger LM, Horak ID. Sapra P, et al. Among authors: mehlig m. Clin Cancer Res. 2008 Mar 15;14(6):1888-96. doi: 10.1158/1078-0432.CCR-07-4456. Clin Cancer Res. 2008. PMID: 18347192

7

Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C. II. Efficacy in ascites and solid tumors.

Choe YH, Conover CD, Wu D, Royzen M, Gervacio Y, Borowski V, Mehlig M, Greenwald RB. Choe YH, et al. Among authors: mehlig m. J Control Release. 2002 Feb 19;79(1-3):55-70. doi: 10.1016/s0168-3659(01)00470-9. J Control Release. 2002. PMID: 11853918

8

Potent and sustained inhibition of HIF-1α and downstream genes by a polyethyleneglycol-SN38 conjugate, EZN-2208, results in anti-angiogenic effects.

Sapra P, Kraft P, Pastorino F, Ribatti D, Dumble M, Mehlig M, Wang M, Ponzoni M, Greenberger LM, Horak ID. Sapra P, et al. Among authors: mehlig m. Angiogenesis. 2011 Sep;14(3):245-53. doi: 10.1007/s10456-011-9209-1. Epub 2011 Mar 31. Angiogenesis. 2011. PMID: 21452059 Free PMC article.

9

Marked therapeutic efficacy of a novel polyethylene glycol-SN38 conjugate, EZN-2208, in xenograft models of B-cell non-Hodgkin's lymphoma.

Sapra P, Kraft P, Mehlig M, Malaby J, Zhao H, Greenberger LM, Horak ID. Sapra P, et al. Among authors: mehlig m. Haematologica. 2009 Oct;94(10):1456-9. doi: 10.3324/haematol.2009.008276. Haematologica. 2009. PMID: 19794091 Free PMC article.

10

Variant toxin B and a functional toxin A produced by Clostridium difficile C34.

Mehlig M, Moos M, Braun V, Kalt B, Mahony DE, von Eichel-Streiber C. Mehlig M, et al. FEMS Microbiol Lett. 2001 May 1;198(2):171-6. doi: 10.1111/j.1574-6968.2001.tb10638.x. FEMS Microbiol Lett. 2001. PMID: 11430410

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