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Page 1
New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.
Singh U, Raju B, Lam S, Zhou J, Gadwood RC, Ford CW, Zurenko GE, Schaadt RD, Morin SE, Adams WJ, Friis JM, Courtney M, Palandra J, Hackbarth CJ, Lopez S, Wu C, Mortell KH, Trias J, Yuan Z, Patel DV, Gordeev MF. Singh U, et al. Among authors: gadwood rc. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4209-12. doi: 10.1016/j.bmcl.2003.07.022. Bioorg Med Chem Lett. 2003. PMID: 14623003
Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
Poel TJ, Thomas RC, Adams WJ, Aristoff PA, Barbachyn MR, Boyer FE, Brieland J, Brideau R, Brodfuehrer J, Brown AP, Choy AL, Dermyer M, Dority M, Ford CW, Gadwood RC, Hanna D, Hongliang C, Huband MD, Huber C, Kelly R, Kim JY, Martin JP Jr, Pagano PJ, Ross D, Skerlos L, Sulavik MC, Zhu T, Zurenko GE, Prasad JV. Poel TJ, et al. Among authors: gadwood rc. J Med Chem. 2007 Nov 29;50(24):5886-9. doi: 10.1021/jm070708p. Epub 2007 Nov 8. J Med Chem. 2007. PMID: 17988109
Design, synthesis, and evaluation of novel oxazolidinone antibacterial agents active against multidrug-resistant bacteria.
Barbachyn MR, Brickner SJ, Gadwood RC, Garmon SA, Grega KC, Hutchinson DK, Munesada K, Reischer RJ, Taniguchi M, Thomasco LM, Toops DS, Yamada H, Ford CW, Zurenko GE. Barbachyn MR, et al. Among authors: gadwood rc. Adv Exp Med Biol. 1998;456:219-38. doi: 10.1007/978-1-4615-4897-3_12. Adv Exp Med Biol. 1998. PMID: 10549371 Review. No abstract available.
Cross-linking in the living cell locates the site of action of oxazolidinone antibiotics.
Colca JR, McDonald WG, Waldon DJ, Thomasco LM, Gadwood RC, Lund ET, Cavey GS, Mathews WR, Adams LD, Cecil ET, Pearson JD, Bock JH, Mott JE, Shinabarger DL, Xiong L, Mankin AS. Colca JR, et al. Among authors: gadwood rc. J Biol Chem. 2003 Jun 13;278(24):21972-9. doi: 10.1074/jbc.M302109200. Epub 2003 Apr 10. J Biol Chem. 2003. PMID: 12690106 Free article.
Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes.
Aoki H, Ke L, Poppe SM, Poel TJ, Weaver EA, Gadwood RC, Thomas RC, Shinabarger DL, Ganoza MC. Aoki H, et al. Among authors: gadwood rc. Antimicrob Agents Chemother. 2002 Apr;46(4):1080-5. doi: 10.1128/AAC.46.4.1080-1085.2002. Antimicrob Agents Chemother. 2002. PMID: 11897593 Free PMC article.
17 results