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New antibacterial tetrahydro-4(2H)-thiopyran and thiomorpholine S-oxide and S,S-dioxide phenyloxazolidinones.
Singh U, Raju B, Lam S, Zhou J, Gadwood RC, Ford CW, Zurenko GE, Schaadt RD, Morin SE, Adams WJ, Friis JM, Courtney M, Palandra J, Hackbarth CJ, Lopez S, Wu C, Mortell KH, Trias J, Yuan Z, Patel DV, Gordeev MF. Singh U, et al. Among authors: zhou j. Bioorg Med Chem Lett. 2003 Dec 1;13(23):4209-12. doi: 10.1016/j.bmcl.2003.07.022. Bioorg Med Chem Lett. 2003. PMID: 14623003
Dihydroxylphenyl amides as inhibitors of the Hsp90 molecular chaperone.
Kung PP, Funk L, Meng J, Collins M, Zhou JZ, Johnson MC, Ekker A, Wang J, Mehta P, Yin MJ, Rodgers C, Davies JF 2nd, Bayman E, Smeal T, Maegley KA, Gehring MR. Kung PP, et al. Among authors: zhou jz. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6273-8. doi: 10.1016/j.bmcl.2008.09.081. Epub 2008 Sep 26. Bioorg Med Chem Lett. 2008. PMID: 18929486
Optimization of potent, selective, and orally bioavailable pyrrolodinopyrimidine-containing inhibitors of heat shock protein 90. Identification of development candidate 2-amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide.
Zehnder L, Bennett M, Meng J, Huang B, Ninkovic S, Wang F, Braganza J, Tatlock J, Jewell T, Zhou JZ, Burke B, Wang J, Maegley K, Mehta PP, Yin MJ, Gajiwala KS, Hickey MJ, Yamazaki S, Smith E, Kang P, Sistla A, Dovalsantos E, Gehring MR, Kania R, Wythes M, Kung PP. Zehnder L, et al. Among authors: zhou jz. J Med Chem. 2011 May 12;54(9):3368-85. doi: 10.1021/jm200128m. Epub 2011 Apr 20. J Med Chem. 2011. PMID: 21438541
Combinatorial library-based design with Basis Products.
Zhou JZ, Shi S, Na J, Peng Z, Thacher T. Zhou JZ, et al. J Comput Aided Mol Des. 2009 Oct;23(10):725-36. doi: 10.1007/s10822-009-9297-9. Epub 2009 Jul 11. J Comput Aided Mol Des. 2009. PMID: 19593647
Structure-directed combinatorial library design.
Zhou JZ. Zhou JZ. Curr Opin Chem Biol. 2008 Jun;12(3):379-85. doi: 10.1016/j.cbpa.2008.02.007. Epub 2008 Mar 20. Curr Opin Chem Biol. 2008. PMID: 18328830 Review.
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