Leffler H - Search Results

1

Efficient and expedient two-step pyranose-retaining fluorescein conjugation of complex reducing oligosaccharides: galectin oligosaccharide specificity studies in a fluorescence polarization assay.

Oberg CT, Carlsson S, Fillion E, Leffler H, Nilsson UJ. Oberg CT, et al. Among authors: leffler h. Bioconjug Chem. 2003 Nov-Dec;14(6):1289-97. doi: 10.1021/bc034130j. Bioconjug Chem. 2003. PMID: 14624646

2

X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.

Lobsanov YD, Gitt MA, Leffler H, Barondes SH, Rini JM. Lobsanov YD, et al. Among authors: leffler h. J Biol Chem. 1993 Dec 25;268(36):27034-8. doi: 10.2210/pdb1hlc/pdb. J Biol Chem. 1993. PMID: 8262940 Free article.

3

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

Seetharaman J, Kanigsberg A, Slaaby R, Leffler H, Barondes SH, Rini JM. Seetharaman J, et al. Among authors: leffler h. J Biol Chem. 1998 May 22;273(21):13047-52. doi: 10.1074/jbc.273.21.13047. J Biol Chem. 1998. PMID: 9582341 Free article.

4

Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine.

Sörme P, Qian Y, Nyholm PG, Leffler H, Nilsson UJ. Sörme P, et al. Among authors: leffler h. Chembiochem. 2002 Mar 1;3(2-3):183-9. doi: 10.1002/1439-7633(20020301)3:2/3<183::aid-cbic183>3.0.co;2-#. Chembiochem. 2002. PMID: 11921396

5

Fluorescence polarization to study galectin-ligand interactions.

Sörme P, Kahl-Knutson B, Wellmar U, Nilsson UJ, Leffler H. Sörme P, et al. Among authors: leffler h. Methods Enzymol. 2003;362:504-12. doi: 10.1016/S0076-6879(03)01033-4. Methods Enzymol. 2003. PMID: 12968384 No abstract available.

6

Design and synthesis of galectin inhibitors.

Sörme P, Kahl-Knutsson B, Wellmar U, Magnusson BG, Leffler H, Nilsson UJ. Sörme P, et al. Among authors: leffler h. Methods Enzymol. 2003;363:157-69. doi: 10.1016/S0076-6879(03)01050-4. Methods Enzymol. 2003. PMID: 14579574 No abstract available.

7

Introduction to galectins.

Leffler H, Carlsson S, Hedlund M, Qian Y, Poirier F. Leffler H, et al. Glycoconj J. 2002;19(7-9):433-40. doi: 10.1023/B:GLYC.0000014072.34840.04. Glycoconj J. 2002. PMID: 14758066 Review.

8

Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions.

Sörme P, Kahl-Knutsson B, Huflejt M, Nilsson UJ, Leffler H. Sörme P, et al. Among authors: leffler h. Anal Biochem. 2004 Nov 1;334(1):36-47. doi: 10.1016/j.ab.2004.06.042. Anal Biochem. 2004. PMID: 15464951

9

Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction.

Sörme P, Arnoux P, Kahl-Knutsson B, Leffler H, Rini JM, Nilsson UJ. Sörme P, et al. Among authors: leffler h. J Am Chem Soc. 2005 Feb 16;127(6):1737-43. doi: 10.1021/ja043475p. J Am Chem Soc. 2005. PMID: 15701008

10

Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors.

Tejler J, Leffler H, Nilsson UJ. Tejler J, et al. Among authors: leffler h. Bioorg Med Chem Lett. 2005 May 2;15(9):2343-5. doi: 10.1016/j.bmcl.2005.02.079. Bioorg Med Chem Lett. 2005. PMID: 15837322 Free article.

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