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Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo.
Friedberg JW, Dong DA, Li S, Kim H, Stephans K, Noonan K, Neuberg D, Gribben JG, Fisher DC, Freedman AS, Takvorian T, Jurgens R, Battle TE, Frank DA. Friedberg JW, et al. Among authors: battle te. Leuk Res. 2004 Feb;28(2):139-47. doi: 10.1016/s0145-2126(03)00213-3. Leuk Res. 2004. PMID: 14654078 Clinical Trial.
The role of STATs in apoptosis.
Battle TE, Frank DA. Battle TE, et al. Curr Mol Med. 2002 Jun;2(4):381-92. doi: 10.2174/1566524023362456. Curr Mol Med. 2002. PMID: 12108949 Review.
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