Vlasuk GP - Search Results

1

Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia.

de Pont AC, Moons AH, de Jonge E, Meijers JC, Vlasuk GP, Rote WE, Büller HR, van der Poll T, Levi M. de Pont AC, et al. Among authors: vlasuk gp. J Thromb Haemost. 2004 Jan;2(1):65-70. doi: 10.1111/j.1538-7836.2004.00526.x. J Thromb Haemost. 2004. PMID: 14717968 Free article. Clinical Trial.

2

Pharmacokinetics and anticoagulant properties of the factor VIIa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man. Dependence on the stoichiometric binding to circulating factor X.

Vlasuk GP, Bradbury A, Lopez-Kinninger L, Colón S, Bergum PW, Maki S, Rote WE. Vlasuk GP, et al. Thromb Haemost. 2003 Nov;90(5):803-12. doi: 10.1160/TH03-05-0265. Thromb Haemost. 2003. PMID: 14597974 Clinical Trial.

3

Inhibition of the tissue factor/factor VIIa pathway does not influence the inflammatory or antibacterial response to abdominal sepsis induced by Escherichia coli in mice.

Weijer S, Schoenmakers SH, Florquin S, Levi M, Vlasuk GP, Rote WE, Reitsma PH, Spek CA, van der Poll T. Weijer S, et al. Among authors: vlasuk gp. J Infect Dis. 2004 Jun 15;189(12):2308-17. doi: 10.1086/421031. Epub 2004 May 25. J Infect Dis. 2004. PMID: 15181580

4

Endotoxaemia induces resistance to activated protein C in healthy humans.

de Pont AC, Bakhtiari K, Hutten BA, de Jonge E, Vlasuk GP, Rote WE, Levi M, Büller HR, Meijers JC. de Pont AC, et al. Among authors: vlasuk gp. Br J Haematol. 2006 Jul;134(2):213-9. doi: 10.1111/j.1365-2141.2006.06127.x. Br J Haematol. 2006. PMID: 16846480 Free article.

5

Recombinant nematode anticoagulant protein c2, a novel inhibitor of tissue factor-factor VIIa activity, abrogates endotoxin-induced coagulation in chimpanzees.

Moons AH, Peters RJ, Cate Ht, Bauer KA, Vlasuk GP, Büller HR, Levi M. Moons AH, et al. Among authors: vlasuk gp. Thromb Haemost. 2002 Oct;88(4):627-31. Thromb Haemost. 2002. PMID: 12362234

6

Activation of coagulation by administration of recombinant factor VIIa elicits interleukin 6 (IL-6) and IL-8 release in healthy human subjects.

de Jonge E, Friederich PW, Vlasuk GP, Rote WE, Vroom MB, Levi M, van der Poll T. de Jonge E, et al. Among authors: vlasuk gp. Clin Diagn Lab Immunol. 2003 May;10(3):495-7. doi: 10.1128/cdli.10.3.495-497.2003. Clin Diagn Lab Immunol. 2003. PMID: 12738659 Free PMC article.

7

Recombinant nematode anticoagulant protein c2, an inhibitor of the tissue factor/factor VIIa complex, in patients undergoing elective coronary angioplasty.

Moons AH, Peters RJ, Bijsterveld NR, Piek JJ, Prins MH, Vlasuk GP, Rote WE, Büller HR. Moons AH, et al. Among authors: vlasuk gp. J Am Coll Cardiol. 2003 Jun 18;41(12):2147-53. doi: 10.1016/s0735-1097(03)00478-9. J Am Coll Cardiol. 2003. PMID: 12821239 Free article. Clinical Trial.

8

Inhibition of factor VIIa/tissue factor with nematode anticoagulant protein c2: from unique mechanism to a promising new clinical anticoagulant.

Vlasuk GP, Rote WE. Vlasuk GP, et al. Trends Cardiovasc Med. 2002 Nov;12(8):325-31. doi: 10.1016/s1050-1738(02)00185-8. Trends Cardiovasc Med. 2002. PMID: 12536118 Review.

9

Ability of recombinant factor VIIa to generate thrombin during inhibition of tissue factor in human subjects.

Friederich PW, Levi M, Bauer KA, Vlasuk GP, Rote WE, Breederveld D, Keller T, Spataro M, Barzegar S, Büller HR. Friederich PW, et al. Among authors: vlasuk gp. Circulation. 2001 May 29;103(21):2555-9. doi: 10.1161/01.cir.103.21.2555. Circulation. 2001. PMID: 11382723 Clinical Trial.

10

Local activation of the tissue factor-factor VIIa pathway in patients with pneumonia and the effect of inhibition of this pathway in murine pneumococcal pneumonia.

Rijneveld AW, Weijer S, Bresser P, Florquin S, Vlasuk GP, Rote WE, Spek CA, Reitsma PH, van der Zee JS, Levi M, van der Poll T. Rijneveld AW, et al. Among authors: vlasuk gp. Crit Care Med. 2006 Jun;34(6):1725-30. doi: 10.1097/01.CCM.0000218807.20570.C2. Crit Care Med. 2006. PMID: 16625114

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