Welsh WJ - Search Results

1

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

Tabb MM, Kholodovych V, Grün F, Zhou C, Welsh WJ, Blumberg B. Tabb MM, et al. Among authors: welsh wj. Environ Health Perspect. 2004 Feb;112(2):163-9. doi: 10.1289/ehp.6560. Environ Health Perspect. 2004. PMID: 14754570 Free PMC article.

2

Bisphenol A and its analogues activate human pregnane X receptor.

Sui Y, Ai N, Park SH, Rios-Pilier J, Perkins JT, Welsh WJ, Zhou C. Sui Y, et al. Among authors: welsh wj. Environ Health Perspect. 2012 Mar;120(3):399-405. doi: 10.1289/ehp.1104426. Epub 2012 Jan 3. Environ Health Perspect. 2012. PMID: 22214767 Free PMC article.

3

Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.

Ekins S, Chang C, Mani S, Krasowski MD, Reschly EJ, Iyer M, Kholodovych V, Ai N, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachmann K. Ekins S, et al. Among authors: welsh wj. Mol Pharmacol. 2007 Sep;72(3):592-603. doi: 10.1124/mol.107.038398. Epub 2007 Jun 18. Mol Pharmacol. 2007. PMID: 17576789

4

Computational discovery of novel low micromolar human pregnane X receptor antagonists.

Ekins S, Kholodovych V, Ai N, Sinz M, Gal J, Gera L, Welsh WJ, Bachmann K, Mani S. Ekins S, et al. Among authors: welsh wj. Mol Pharmacol. 2008 Sep;74(3):662-72. doi: 10.1124/mol.108.049437. Epub 2008 Jun 25. Mol Pharmacol. 2008. PMID: 18579710

5

Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.

Helsley RN, Sui Y, Ai N, Park SH, Welsh WJ, Zhou C. Helsley RN, et al. Among authors: welsh wj. Mol Pharmacol. 2013 Jun;83(6):1190-9. doi: 10.1124/mol.113.085753. Epub 2013 Mar 21. Mol Pharmacol. 2013. PMID: 23519392 Free PMC article.

6

Volume learning algorithm significantly improved PLS model for predicting the estrogenic activity of xenoestrogens.

Kovalishyn VV, Kholodovych V, Tetko IV, Welsh WJ. Kovalishyn VV, et al. Among authors: welsh wj. J Mol Graph Model. 2007 Sep;26(2):591-4. doi: 10.1016/j.jmgm.2007.03.005. Epub 2007 Mar 19. J Mol Graph Model. 2007. PMID: 17433745

7

The major human pregnane X receptor (PXR) splice variant, PXR.2, exhibits significantly diminished ligand-activated transcriptional regulation.

Lin YS, Yasuda K, Assem M, Cline C, Barber J, Li CW, Kholodovych V, Ai N, Chen JD, Welsh WJ, Ekins S, Schuetz EG. Lin YS, et al. Among authors: welsh wj. Drug Metab Dispos. 2009 Jun;37(6):1295-304. doi: 10.1124/dmd.108.025213. Epub 2009 Feb 27. Drug Metab Dispos. 2009. PMID: 19251824 Free PMC article.

8

Using surrogate modeling in the prediction of fibrinogen adsorption onto polymer surfaces.

Smith JR, Knight D, Kohn J, Rasheed K, Weber N, Kholodovych V, Welsh WJ. Smith JR, et al. Among authors: welsh wj. J Chem Inf Comput Sci. 2004 May-Jun;44(3):1088-97. doi: 10.1021/ci0499774. J Chem Inf Comput Sci. 2004. PMID: 15154777

9

Logical Analysis of Data in Structure-Activity Investigation of Polymeric Gene Delivery.

Gubskaya AV, Bonates TO, Kholodovych V, Hammer P, Welsh WJ, Langer R, Kohn J. Gubskaya AV, et al. Among authors: welsh wj. Macromol Theory Simul. 2011 May 23;20(4):275-285. doi: 10.1002/mats.201000087. Macromol Theory Simul. 2011. PMID: 25663794 Free PMC article.

10

Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.

Paranjpe PV, Chen Y, Kholodovych V, Welsh W, Stein S, Sinko PJ. Paranjpe PV, et al. J Control Release. 2004 Nov 24;100(2):275-92. doi: 10.1016/j.jconrel.2004.08.030. J Control Release. 2004. PMID: 15544875

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