Pearl L - Search Results

1

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.

Polychronopoulos P, Magiatis P, Skaltsounis AL, Myrianthopoulos V, Mikros E, Tarricone A, Musacchio A, Roe SM, Pearl L, Leost M, Greengard P, Meijer L. Polychronopoulos P, et al. Among authors: pearl l. J Med Chem. 2004 Feb 12;47(4):935-46. doi: 10.1021/jm031016d. J Med Chem. 2004. PMID: 14761195

2

GSK-3-selective inhibitors derived from Tyrian purple indirubins.

Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. Meijer L, et al. Among authors: pearl l. Chem Biol. 2003 Dec;10(12):1255-66. doi: 10.1016/j.chembiol.2003.11.010. Chem Biol. 2003. PMID: 14700633

3

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.

Fugel W, Oberholzer AE, Gschloessl B, Dzikowski R, Pressburger N, Preu L, Pearl LH, Baratte B, Ratin M, Okun I, Doerig C, Kruggel S, Lemcke T, Meijer L, Kunick C. Fugel W, et al. Among authors: pearl lh. J Med Chem. 2013 Jan 10;56(1):264-75. doi: 10.1021/jm301575n. Epub 2012 Dec 27. J Med Chem. 2013. PMID: 23214499

4

Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.

Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Roe SM, et al. Among authors: pearl lh. J Med Chem. 1999 Jan 28;42(2):260-6. doi: 10.1021/jm980403y. J Med Chem. 1999. PMID: 9925731

5

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Cheung KM, Matthews TP, James K, Rowlands MG, Boxall KJ, Sharp SY, Maloney A, Roe SM, Prodromou C, Pearl LH, Aherne GW, McDonald E, Workman P. Cheung KM, et al. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3338-43. doi: 10.1016/j.bmcl.2005.05.046. Bioorg Med Chem Lett. 2005. PMID: 15955698

6

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, Meijer L. Tahtouh T, et al. Among authors: pearl lh. J Med Chem. 2012 Nov 8;55(21):9312-30. doi: 10.1021/jm301034u. Epub 2012 Oct 8. J Med Chem. 2012. PMID: 22998443

7

Inhibition of Hsp90 with synthetic macrolactones: synthesis and structural and biological evaluation of ring and conformational analogs of radicicol.

Proisy N, Sharp SY, Boxall K, Connelly S, Roe SM, Prodromou C, Slawin AM, Pearl LH, Workman P, Moody CJ. Proisy N, et al. Chem Biol. 2006 Nov;13(11):1203-15. doi: 10.1016/j.chembiol.2006.09.015. Chem Biol. 2006. PMID: 17114002

8

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition.

Dajani R, Fraser E, Roe SM, Young N, Good V, Dale TC, Pearl LH. Dajani R, et al. Among authors: pearl lh. Cell. 2001 Jun 15;105(6):721-32. doi: 10.1016/s0092-8674(01)00374-9. Cell. 2001. PMID: 11440715 Free article.

9

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors.

Droucheau E, Primot A, Thomas V, Mattei D, Knockaert M, Richardson C, Sallicandro P, Alano P, Jafarshad A, Baratte B, Kunick C, Parzy D, Pearl L, Doerig C, Meijer L. Droucheau E, et al. Among authors: pearl l. Biochim Biophys Acta. 2004 Mar 11;1697(1-2):181-96. doi: 10.1016/j.bbapap.2003.11.023. Biochim Biophys Acta. 2004. PMID: 15023360 Review.

10

Optimizing natural products by biosynthetic engineering: discovery of nonquinone Hsp90 inhibitors.

Zhang MQ, Gaisser S, Nur-E-Alam M, Sheehan LS, Vousden WA, Gaitatzis N, Peck G, Coates NJ, Moss SJ, Radzom M, Foster TA, Sheridan RM, Gregory MA, Roe SM, Prodromou C, Pearl L, Boyd SM, Wilkinson B, Martin CJ. Zhang MQ, et al. Among authors: pearl l. J Med Chem. 2008 Sep 25;51(18):5494-7. doi: 10.1021/jm8006068. J Med Chem. 2008. PMID: 18800759

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