Hartley JA - Search Results

1

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. Among authors: hartley ja. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

2

DNA cross-linking and sequence selectivity of aziridinylbenzoquinones: a unique reaction at 5'-GC-3' sequences with 2,5-diaziridinyl-1,4-benzoquinone upon reduction.

Hartley JA, Berardini M, Ponti M, Gibson NW, Thompson AS, Thurston DE, Hoey BM, Butler J. Hartley JA, et al. Biochemistry. 1991 Dec 17;30(50):11719-24. doi: 10.1021/bi00114a016. Biochemistry. 1991. PMID: 1751490

3

N2,N4,N6-tri(hydroxymethyl)-N2,N4,N6-trimethylmelamine (trimelamol) is an efficient DNA cross-linking agent in vitro.

Jackson C, Hartley JA, Jenkins TC, Godfrey R, Saunders R, Thurston DE. Jackson C, et al. Among authors: hartley ja. Biochem Pharmacol. 1991 Nov 6;42(11):2091-7. doi: 10.1016/0006-2952(91)90343-4. Biochem Pharmacol. 1991. PMID: 1958227

4

Novel cytotoxic DNA sequence and minor groove targeted photosensitizers: conjugates of pyrene and netropsin analogues.

Hartley JA, Webber J, Wyatt MD, Bordenick N, Lee M. Hartley JA, et al. Bioorg Med Chem. 1995 Jun;3(6):623-9. doi: 10.1016/0968-0896(95)00050-q. Bioorg Med Chem. 1995. PMID: 7582941

5

Cellular pharmacology of novel C8-linked anthramycin-based sequence-selective DNA minor groove cross-linking agents.

Smellie M, Kelland LR, Thurston DE, Souhami RL, Hartley JA. Smellie M, et al. Among authors: hartley ja. Br J Cancer. 1994 Jul;70(1):48-53. doi: 10.1038/bjc.1994.248. Br J Cancer. 1994. PMID: 8018540 Free PMC article.

6

In vitro photoinduced cytotoxicity and DNA binding properties of psoralen and coumarin conjugates of netropsin analogues: DNA sequence-directed alkylation and cross-link formation.

Lee M, Roldan MC, Haskell MK, McAdam SR, Hartley JA. Lee M, et al. Among authors: hartley ja. J Med Chem. 1994 Apr 15;37(8):1208-13. doi: 10.1021/jm00034a019. J Med Chem. 1994. PMID: 8164263

7

A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonuclease BamHI.

Puvvada MS, Hartley JA, Jenkins TC, Thurston DE. Puvvada MS, et al. Among authors: hartley ja. Nucleic Acids Res. 1993 Aug 11;21(16):3671-5. doi: 10.1093/nar/21.16.3671. Nucleic Acids Res. 1993. PMID: 8367284 Free PMC article.

8

Cross-linking and sequence specific alkylation of DNA BY aziridinylquinones. 1. Quinone methides.

Mayalarp SP, Hargreaves RH, Butler J, O'Hare CC, Hartley JA. Mayalarp SP, et al. Among authors: hartley ja. J Med Chem. 1996 Jan 19;39(2):531-7. doi: 10.1021/jm950629q. J Med Chem. 1996. PMID: 8558523

9

Cross-linking and sequence specific alkylation of DNA by aziridinyl quinones. 2. Structure requirements for sequence selectivity.

Hargreaves RH, Mayalarp SP, Butler J, McAdam SR, O'Hare CC, Hartley JA. Hargreaves RH, et al. Among authors: hartley ja. J Med Chem. 1997 Jan 31;40(3):357-61. doi: 10.1021/jm960492j. J Med Chem. 1997. PMID: 9022802

10

Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines.

Puvvada MS, Forrow SA, Hartley JA, Stephenson P, Gibson I, Jenkins TC, Thurston DE. Puvvada MS, et al. Among authors: hartley ja. Biochemistry. 1997 Mar 4;36(9):2478-84. doi: 10.1021/bi952490r. Biochemistry. 1997. PMID: 9054552

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