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Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset.
Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS Jr, Landwehrmeyer B; U.S.-Venezuela Collaborative Research Project. Wexler NS, et al. Among authors: fischbeck k. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3498-503. doi: 10.1073/pnas.0308679101. Epub 2004 Mar 1. Proc Natl Acad Sci U S A. 2004. PMID: 14993615 Free PMC article.
Oligonucleotide Treatment for Huntington's Disease.
Fischbeck KH, Wexler NS. Fischbeck KH, et al. N Engl J Med. 2019 Jun 13;380(24):2373-2374. doi: 10.1056/NEJMe1904861. Epub 2019 May 6. N Engl J Med. 2019. PMID: 31059640 No abstract available.
Histone deacetylase inhibitors reduce polyglutamine toxicity.
McCampbell A, Taye AA, Whitty L, Penney E, Steffan JS, Fischbeck KH. McCampbell A, et al. Among authors: fischbeck kh. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15179-84. doi: 10.1073/pnas.261400698. Epub 2001 Dec 11. Proc Natl Acad Sci U S A. 2001. PMID: 11742087 Free PMC article.
278 results