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Page 1
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity.
Sauerberg P, Pettersson I, Jeppesen L, Bury PS, Mogensen JP, Wassermann K, Brand CL, Sturis J, Wöldike HF, Fleckner J, Andersen AS, Mortensen SB, Svensson LA, Rasmussen HB, Lehmann SV, Polivka Z, Sindelar K, Panajotova V, Ynddal L, Wulff EM. Sauerberg P, et al. Among authors: wulff em. J Med Chem. 2002 Feb 14;45(4):789-804. doi: 10.1021/jm010964g. J Med Chem. 2002. PMID: 11831892
Design and synthesis of novel PPARalpha/gamma/delta triple activators using a known PPARalpha/gamma dual activator as structural template.
Mogensen JP, Jeppesen L, Bury PS, Pettersson I, Fleckner J, Nehlin J, Frederiksen KS, Albrektsen T, Din N, Mortensen SB, Svensson LA, Wassermann K, Wulff EM, Ynddal L, Sauerberg P. Mogensen JP, et al. Among authors: wulff em. Bioorg Med Chem Lett. 2003 Jan 20;13(2):257-60. doi: 10.1016/s0960-894x(02)00881-8. Bioorg Med Chem Lett. 2003. PMID: 12482434
Structure-activity relationships of dimeric PPAR agonists.
Sauerberg P, Mogensen JP, Jeppesen L, Svensson LA, Fleckner J, Nehlin J, Wulff EM, Pettersson I. Sauerberg P, et al. Among authors: wulff em. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1497-500. doi: 10.1016/j.bmcl.2004.12.084. Bioorg Med Chem Lett. 2005. PMID: 15713415
Selective PPAR agonists for the treatment of type 2 diabetes.
Nehlin JO, Mogensen JP, Petterson I, Jeppesen L, Fleckner J, Wulff EM, Sauerberg P. Nehlin JO, et al. Among authors: wulff em. Ann N Y Acad Sci. 2006 May;1067:448-53. doi: 10.1196/annals.1354.064. Ann N Y Acad Sci. 2006. PMID: 16804025 Review.
Identification and synthesis of a novel selective partial PPARdelta agonist with full efficacy on lipid metabolism in vitro and in vivo.
Sauerberg P, Olsen GS, Jeppesen L, Mogensen JP, Pettersson I, Jeppesen CB, Daugaard JR, Galsgaard ED, Ynddal L, Fleckner J, Panajotova V, Polivka Z, Pihera P, Havranek M, Wulff EM. Sauerberg P, et al. Among authors: wulff em. J Med Chem. 2007 Apr 5;50(7):1495-503. doi: 10.1021/jm061202u. Epub 2007 Mar 8. J Med Chem. 2007. PMID: 17343371
Design of potent PPARalpha agonists.
Sauerberg P, Mogensen JP, Jeppesen L, Bury PS, Fleckner J, Olsen GS, Jeppesen CB, Wulff EM, Pihera P, Havranek M, Polivka Z, Pettersson I. Sauerberg P, et al. Among authors: wulff em. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3198-202. doi: 10.1016/j.bmcl.2007.03.015. Epub 2007 Mar 12. Bioorg Med Chem Lett. 2007. PMID: 17379517
22 results