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Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets.
Aravena O, Pesce B, Soto L, Orrego N, Sabugo F, Wurmann P, Molina MC, Alfaro J, Cuchacovich M, Aguillón JC, Catalán D. Aravena O, et al. Among authors: soto l. Immunobiology. 2011 Dec;216(12):1256-63. doi: 10.1016/j.imbio.2011.07.006. Epub 2011 Jul 7. Immunobiology. 2011. PMID: 21840621 Free article.
B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapy.
Catalán D, Aravena O, Sabugo F, Wurmann P, Soto L, Kalergis AM, Cuchacovich M, Aguillón JC; Millenium Nucleus on Immunology and Immunotherapy P-07-088-F. Catalán D, et al. Among authors: soto l. Arthritis Res Ther. 2010;12(2):R68. doi: 10.1186/ar2985. Epub 2010 Apr 15. Arthritis Res Ther. 2010. PMID: 20398308 Free PMC article.
The presence of anti-citrullinated protein antibodies (ACPA) does not affect the clinical response to adalimumab in a group of RA patients with the tumor necrosis factor (TNF) α-308 G/G promoter polymorphism.
Soto L, Sabugo F, Catalan D, Wurmann P, Cermenatti T, Gatica H, Aravena O, Salazar L, Aguillón JC, Cuchacovich M. Soto L, et al. Clin Rheumatol. 2011 Mar;30(3):391-5. doi: 10.1007/s10067-011-1679-4. Epub 2011 Jan 14. Clin Rheumatol. 2011. PMID: 21234628
The -308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide-induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis.
Cuenca J, Cuchacovich M, Pérez C, Ferreira L, Aguirre A, Schiattino I, Soto L, Cruzat A, Salazar-Onfray F, Aguillón JC. Cuenca J, et al. Among authors: soto l. Rheumatology (Oxford). 2003 Feb;42(2):308-13. doi: 10.1093/rheumatology/keg092. Rheumatology (Oxford). 2003. PMID: 12595628
329 results