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5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
Schneider-Stock R, Diab-Assef M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C, Hartig R, Schönfeld P, Roessner A, Gali-Muhtasib H. Schneider-Stock R, et al. Among authors: rohrbeck a. J Pharmacol Exp Ther. 2005 Feb;312(2):525-36. doi: 10.1124/jpet.104.074195. Epub 2004 Nov 16. J Pharmacol Exp Ther. 2005. Retraction in: J Pharmacol Exp Ther. 2016 Oct;359(1):90. doi: 10.1124/jpet.113.074195retraction PMID: 15547111 Retracted.
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