Decicco CP - Search Results

1

Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.

Wang X, Feuerstein GZ, Xu L, Wang H, Schumacher WA, Ogletree ML, Taub R, Duan JJ, Decicco CP, Liu RQ. Wang X, et al. Among authors: decicco cp. Mol Pharmacol. 2004 Apr;65(4):890-6. doi: 10.1124/mol.65.4.890. Mol Pharmacol. 2004. PMID: 15044618

2

Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.

Cherney RJ, Duan JJ, Voss ME, Chen L, Wang L, Meyer DT, Wasserman ZR, Hardman KD, Liu RQ, Covington MB, Qian M, Mandlekar S, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Cherney RJ, et al. Among authors: decicco cp. J Med Chem. 2003 May 8;46(10):1811-23. doi: 10.1021/jm020475w. J Med Chem. 2003. PMID: 12723945

3

Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Duan JJ, Lu Z, Xue CB, He X, Seng JL, Roderick JJ, Wasserman ZR, Liu RQ, Covington MB, Magolda RL, Newton RC, Trzaskos JM, Decicco CP. Duan JJ, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2035-40. doi: 10.1016/s0960-894x(03)00313-5. Bioorg Med Chem Lett. 2003. PMID: 12781190

4

Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.

Duan JJ, Lu Z, Wasserman ZR, Liu RQ, Covington MB, Decicco CP. Duan JJ, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2005 Jun 15;15(12):2970-3. doi: 10.1016/j.bmcl.2005.04.039. Bioorg Med Chem Lett. 2005. PMID: 15908214

5

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Duan JJ, Chen L, Lu Z, Jiang B, Asakawa N, Sheppeck JE 2nd, Liu RQ, Covington MB, Pitts W, Kim SH, Decicco CP. Duan JJ, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2007 Jan 1;17(1):266-71. doi: 10.1016/j.bmcl.2006.09.048. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17027261

6

Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Sheppeck JE 2nd, Gilmore JL, Yang A, Chen XT, Xue CB, Roderick J, Liu RQ, Covington MB, Decicco CP, Duan JJ. Sheppeck JE 2nd, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1413-7. doi: 10.1016/j.bmcl.2006.11.089. Epub 2006 Dec 2. Bioorg Med Chem Lett. 2007. PMID: 17188863

7

Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.

Duan JJ, Chen L, Wasserman ZR, Lu Z, Liu RQ, Covington MB, Qian M, Hardman KD, Magolda RL, Newton RC, Christ DD, Wexler RR, Decicco CP. Duan JJ, et al. Among authors: decicco cp. J Med Chem. 2002 Nov 7;45(23):4954-7. doi: 10.1021/jm0255670. J Med Chem. 2002. PMID: 12408705

8

Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.

Wasserman ZR, Duan JJ, Voss ME, Xue CB, Cherney RJ, Nelson DJ, Hardman KD, Decicco CP. Wasserman ZR, et al. Among authors: decicco cp. Chem Biol. 2003 Mar;10(3):215-23. doi: 10.1016/s1074-5521(03)00044-9. Chem Biol. 2003. PMID: 12670535

9

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 1: lead identification.

Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4293-7. doi: 10.1016/j.bmcl.2003.09.056. Bioorg Med Chem Lett. 2003. PMID: 14643312

10

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.

Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Qian M, Ribadeneira MD, Vaddi K, Christ DD, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP. Xue CB, et al. Among authors: decicco cp. Bioorg Med Chem Lett. 2003 Dec 15;13(24):4299-304. doi: 10.1016/j.bmcl.2003.09.057. Bioorg Med Chem Lett. 2003. PMID: 14643313

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