Duan JJ - Search Results

1

Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats.

Wang X, Feuerstein GZ, Xu L, Wang H, Schumacher WA, Ogletree ML, Taub R, Duan JJ, Decicco CP, Liu RQ. Wang X, et al. Among authors: duan jj. Mol Pharmacol. 2004 Apr;65(4):890-6. doi: 10.1124/mol.65.4.890. Mol Pharmacol. 2004. PMID: 15044618

2

Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.

Duan JJ, Chen L, Wasserman ZR, Lu Z, Liu RQ, Covington MB, Qian M, Hardman KD, Magolda RL, Newton RC, Christ DD, Wexler RR, Decicco CP. Duan JJ, et al. J Med Chem. 2002 Nov 7;45(23):4954-7. doi: 10.1021/jm0255670. J Med Chem. 2002. PMID: 12408705

3

Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.

Cherney RJ, Duan JJ, Voss ME, Chen L, Wang L, Meyer DT, Wasserman ZR, Hardman KD, Liu RQ, Covington MB, Qian M, Mandlekar S, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP. Cherney RJ, et al. Among authors: duan jj. J Med Chem. 2003 May 8;46(10):1811-23. doi: 10.1021/jm020475w. J Med Chem. 2003. PMID: 12723945

4

Discovery of N-hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Duan JJ, Lu Z, Xue CB, He X, Seng JL, Roderick JJ, Wasserman ZR, Liu RQ, Covington MB, Magolda RL, Newton RC, Trzaskos JM, Decicco CP. Duan JJ, et al. Bioorg Med Chem Lett. 2003 Jun 16;13(12):2035-40. doi: 10.1016/s0960-894x(03)00313-5. Bioorg Med Chem Lett. 2003. PMID: 12781190

5

Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.

Duan JJ, Lu Z, Wasserman ZR, Liu RQ, Covington MB, Decicco CP. Duan JJ, et al. Bioorg Med Chem Lett. 2005 Jun 15;15(12):2970-3. doi: 10.1016/j.bmcl.2005.04.039. Bioorg Med Chem Lett. 2005. PMID: 15908214

6

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Duan JJ, Chen L, Lu Z, Jiang B, Asakawa N, Sheppeck JE 2nd, Liu RQ, Covington MB, Pitts W, Kim SH, Decicco CP. Duan JJ, et al. Bioorg Med Chem Lett. 2007 Jan 1;17(1):266-71. doi: 10.1016/j.bmcl.2006.09.048. Epub 2006 Oct 5. Bioorg Med Chem Lett. 2007. PMID: 17027261

7

Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Sheppeck JE 2nd, Gilmore JL, Yang A, Chen XT, Xue CB, Roderick J, Liu RQ, Covington MB, Decicco CP, Duan JJ. Sheppeck JE 2nd, et al. Among authors: duan jj. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1413-7. doi: 10.1016/j.bmcl.2006.11.089. Epub 2006 Dec 2. Bioorg Med Chem Lett. 2007. PMID: 17188863

8

Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Sheppeck JE 2nd, Gilmore JL, Tebben A, Xue CB, Liu RQ, Decicco CP, Duan JJ. Sheppeck JE 2nd, et al. Among authors: duan jj. Bioorg Med Chem Lett. 2007 May 15;17(10):2769-74. doi: 10.1016/j.bmcl.2007.02.076. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17368021

9

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.

Qian M, Bai SA, Brogdon B, Wu JT, Liu RQ, Covington MB, Vaddi K, Newton RC, Fossler MJ, Garner CE, Deng Y, Maduskuie T, Trzaskos J, Duan JJ, Decicco CP, Christ DD. Qian M, et al. Among authors: duan jj. Drug Metab Dispos. 2007 Oct;35(10):1916-25. doi: 10.1124/dmd.107.015933. Epub 2007 Jul 26. Drug Metab Dispos. 2007. PMID: 17656469 Clinical Trial.

10

Identification of a selectivity determinant for inhibition of tumor necrosis factor-alpha converting enzyme by comparative modeling.

Wasserman ZR, Duan JJ, Voss ME, Xue CB, Cherney RJ, Nelson DJ, Hardman KD, Decicco CP. Wasserman ZR, et al. Among authors: duan jj. Chem Biol. 2003 Mar;10(3):215-23. doi: 10.1016/s1074-5521(03)00044-9. Chem Biol. 2003. PMID: 12670535

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