Watson MA - Search Results

1

Recombinant baculoviruses used to study estrogen receptor function in human osteosarcoma cells.

Clay WC, Condreay JP, Moore LB, Weaver SL, Watson MA, Kost TA, Lorenz JJ. Clay WC, et al. Among authors: watson ma. Assay Drug Dev Technol. 2003 Dec;1(6):801-10. doi: 10.1089/154065803772613435. Assay Drug Dev Technol. 2003. PMID: 15090226

2

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.

Williams S, Bledsoe RK, Collins JL, Boggs S, Lambert MH, Miller AB, Moore J, McKee DD, Moore L, Nichols J, Parks D, Watson M, Wisely B, Willson TM. Williams S, et al. J Biol Chem. 2003 Jul 18;278(29):27138-43. doi: 10.1074/jbc.M302260200. Epub 2003 May 7. J Biol Chem. 2003. PMID: 12736258 Free article.

3

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA. Goodwin B, et al. Among authors: watson ma. Mol Cell. 2000 Sep;6(3):517-26. doi: 10.1016/s1097-2765(00)00051-4. Mol Cell. 2000. PMID: 11030332 Free article.

4

Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.

Collins JL, Fivush AM, Watson MA, Galardi CM, Lewis MC, Moore LB, Parks DJ, Wilson JG, Tippin TK, Binz JG, Plunket KD, Morgan DG, Beaudet EJ, Whitney KD, Kliewer SA, Willson TM. Collins JL, et al. Among authors: watson ma. J Med Chem. 2002 May 9;45(10):1963-6. doi: 10.1021/jm0255116. J Med Chem. 2002. PMID: 11985463

5

Pharmacophore analysis of the nuclear oxysterol receptor LXRalpha.

Spencer TA, Li D, Russel JS, Collins JL, Bledsoe RK, Consler TG, Moore LB, Galardi CM, McKee DD, Moore JT, Watson MA, Parks DJ, Lambert MH, Willson TM. Spencer TA, et al. Among authors: watson ma. J Med Chem. 2001 Mar 15;44(6):886-97. doi: 10.1021/jm0004749. J Med Chem. 2001. PMID: 11300870

6

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.

Goodwin B, Watson MA, Kim H, Miao J, Kemper JK, Kliewer SA. Goodwin B, et al. Among authors: watson ma. Mol Endocrinol. 2003 Mar;17(3):386-94. doi: 10.1210/me.2002-0246. Epub 2002 Dec 12. Mol Endocrinol. 2003. PMID: 12554795

7

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.

Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA. Whitney KD, et al. Among authors: watson ma. J Biol Chem. 2001 Nov 23;276(47):43509-15. doi: 10.1074/jbc.M106155200. Epub 2001 Aug 23. J Biol Chem. 2001. PMID: 11546778 Free article.

8

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.

Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, Kliewer SA. Whitney KD, et al. Among authors: watson ma. Mol Endocrinol. 2002 Jun;16(6):1378-85. doi: 10.1210/mend.16.6.0835. Mol Endocrinol. 2002. PMID: 12040022

9

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Jaye MC, et al. Among authors: watson ma. J Med Chem. 2005 Aug 25;48(17):5419-22. doi: 10.1021/jm050532w. J Med Chem. 2005. PMID: 16107141

10

The relative transcription index: a gene expression based metric for prioritization of drug candidates.

Ghosh S, Watson MA, Collins JL. Ghosh S, et al. Among authors: watson ma. Comb Chem High Throughput Screen. 2007 May;10(4):239-45. doi: 10.2174/138620707780636628. Comb Chem High Throughput Screen. 2007. PMID: 17506706

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