Aharony D - Search Results

1

Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists.

Ohnmacht CJ, Albert JS, Bernstein PR, Rumsey WL, Masek BB, Dembofsky BT, Koether GM, Andisik DW, Aharony D. Ohnmacht CJ, et al. Among authors: aharony d. Bioorg Med Chem. 2004 May 15;12(10):2653-69. doi: 10.1016/j.bmc.2004.03.015. Bioorg Med Chem. 2004. PMID: 15110847

2

Design, synthesis, and SAR of tachykinin antagonists: modulation of balance in NK(1)/NK(2) receptor antagonist activity.

Albert JS, Aharony D, Andisik D, Barthlow H, Bernstein PR, Bialecki RA, Dedinas R, Dembofsky BT, Hill D, Kirkland K, Koether GM, Kosmider BJ, Ohnmacht C, Palmer W, Potts W, Rumsey W, Shen L, Shenvi A, Sherwood S, Warwick PJ, Russell K. Albert JS, et al. Among authors: aharony d. J Med Chem. 2002 Aug 29;45(18):3972-83. doi: 10.1021/jm020094i. J Med Chem. 2002. PMID: 12190319

3

Structural analysis and optimization of NK(1) receptor antagonists through modulation of atropisomer interconversion properties.

Albert JS, Ohnmacht C, Bernstein PR, Rumsey WL, Aharony D, Alelyunas Y, Russell DJ, Potts W, Sherwood SA, Shen L, Dedinas RF, Palmer WE, Russell K. Albert JS, et al. Among authors: aharony d. J Med Chem. 2004 Jan 29;47(3):519-29. doi: 10.1021/jm030197g. J Med Chem. 2004. PMID: 14736234

4

Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.

Edwards PD, Albert JS, Sylvester M, Aharony D, Andisik D, Callaghan O, Campbell JB, Carr RA, Chessari G, Congreve M, Frederickson M, Folmer RH, Geschwindner S, Koether G, Kolmodin K, Krumrine J, Mauger RC, Murray CW, Olsson LL, Patel S, Spear N, Tian G. Edwards PD, et al. Among authors: aharony d. J Med Chem. 2007 Nov 29;50(24):5912-25. doi: 10.1021/jm070829p. Epub 2007 Nov 7. J Med Chem. 2007. PMID: 17985862

5

Discovery of novel, orally active dual NK1/NK2 antagonists.

Bernstein PR, Aharony D, Albert JS, Andisik D, Barthlow HG, Bialecki R, Davenport T, Dedinas RF, Dembofsky BT, Koether G, Kosmider BJ, Kirkland K, Ohnmacht CJ, Potts W, Rumsey WL, Shen L, Shenvi A, Sherwood S, Stollman D, Russell K. Bernstein PR, et al. Among authors: aharony d. Bioorg Med Chem Lett. 2001 Oct 22;11(20):2769-73. doi: 10.1016/s0960-894x(01)00572-8. Bioorg Med Chem Lett. 2001. PMID: 11591520

6

Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orally active antagonist of leukotrienes D4 and E4.

Jacobs RT, Bernstein PR, Cronk LA, Vacek EP, Newcomb LF, Aharony D, Buckner CK, Kusner EJ. Jacobs RT, et al. Among authors: aharony d. J Med Chem. 1994 Apr 29;37(9):1282-97. doi: 10.1021/jm00035a008. J Med Chem. 1994. PMID: 8176706

7

The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1.

Veale CA, Alford VC, Aharony D, Banville DL, Bialecki RA, Brown FJ, Damewood JR Jr, Dantzman CL, Edwards PD, Jacobs RT, Mauger RC, Murphy MM, Palmer W, Pine KK, Rumsey WL, Garcia-Davenport LE, Shaw A, Steelman GB, Surian JM, Vacek EP. Veale CA, et al. Among authors: aharony d. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52. doi: 10.1016/s0960-894x(00)00387-5. Bioorg Med Chem Lett. 2000. PMID: 10987424

8

Pharmacological characterization of ZD6021: a novel, orally active antagonist of the tachykinin receptors.

Rumsey WL, Aharony D, Bialecki RA, Abbott BM, Barthlow HG, Caccese R, Ghanekar S, Lengel D, McCarthy M, Wenrich B, Undem B, Ohnmacht C, Shenvi A, Albert JS, Brown F, Bernstein PR, Russell K. Rumsey WL, et al. Among authors: aharony d. J Pharmacol Exp Ther. 2001 Jul;298(1):307-15. J Pharmacol Exp Ther. 2001. PMID: 11408556

9

Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.

Brown DG, Bernstein PR, Wu Y, Urbanek RA, Becker CW, Throner SR, Dembofsky BT, Steelman GB, Lazor LA, Scott CW, Wood MW, Wesolowski SS, Nugiel DA, Koch S, Yu J, Pivonka DE, Li S, Thompson C, Zacco A, Elmore CS, Schroeder P, Liu J, Hurley CA, Ward S, Hunt HJ, Williams K, McLaughlin J, Hoesch V, Sydserff S, Maier D, Aharony D. Brown DG, et al. Among authors: aharony d. ACS Med Chem Lett. 2012 Nov 12;4(1):46-51. doi: 10.1021/ml300262e. eCollection 2013 Jan 10. ACS Med Chem Lett. 2012. PMID: 24900562 Free PMC article.

10

4-Alkylpiperidines related to SR-48968: potent antagonists of the neurokinin-2 (NK2) receptor.

Jacobs RT, Shenvi AB, Mauger RC, Ulatowski TG, Aharony D, Buckner CK. Jacobs RT, et al. Among authors: aharony d. Bioorg Med Chem Lett. 1998 Jul 21;8(14):1935-40. doi: 10.1016/s0960-894x(98)00037-7. Bioorg Med Chem Lett. 1998. PMID: 9873462

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

67 results

Search Page

Filters