Ohigashi H - Search Results

1

Indolactam and benzolactam compounds as new medicinal leads with binding selectivity for C1 domains of protein kinase C isozymes.

Irie K, Nakagawa Y, Ohigashi H. Irie K, et al. Among authors: ohigashi h. Curr Pharm Des. 2004;10(12):1371-85. doi: 10.2174/1381612043384907. Curr Pharm Des. 2004. PMID: 15134488 Review.

2

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity.

Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, Saito N. Irie K, et al. Among authors: ohigashi h. Pharmacol Ther. 2002 Feb-Mar;93(2-3):271-81. doi: 10.1016/s0163-7258(02)00196-1. Pharmacol Ther. 2002. PMID: 12191619 Review.

3

Binding selectivity of conformationally restricted analogues of (-)-indolactam-V to the C1 domains of protein kinase C isozymes.

Masuda A, Irie K, Nakagawa Y, Ohigashi H. Masuda A, et al. Among authors: ohigashi h. Biosci Biotechnol Biochem. 2002 Jul;66(7):1615-7. doi: 10.1271/bbb.66.1615. Biosci Biotechnol Biochem. 2002. PMID: 12224655 Free article.

4

Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes.

Nakagawa Y, Irie K, Yamanaka N, Ohigashi H, Tsuda K. Nakagawa Y, et al. Among authors: ohigashi h. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3015-9. doi: 10.1016/s0960-894x(03)00637-1. Bioorg Med Chem Lett. 2003. PMID: 12941324

5

Tumor promoter binding of the protein kinase C C1 homology domain peptides of RasGRPs, chimaerins, and Unc13s.

Irie K, Masuda A, Shindo M, Nakagawa Y, Ohigashi H. Irie K, et al. Among authors: ohigashi h. Bioorg Med Chem. 2004 Sep 1;12(17):4575-83. doi: 10.1016/j.bmc.2004.07.008. Bioorg Med Chem. 2004. PMID: 15358285

6

Indolactam-V is involved in the CH/pi interaction with Pro-11 of the PKCdelta C1B domain: application for the structural optimization of the PKCdelta ligand.

Nakagawa Y, Irie K, Yanagita RC, Ohigashi H, Tsuda K. Nakagawa Y, et al. Among authors: ohigashi h. J Am Chem Soc. 2005 Apr 27;127(16):5746-7. doi: 10.1021/ja050447d. J Am Chem Soc. 2005. PMID: 15839646

7

Toward the development of new medicinal leads with selectivity for protein kinase C isozymes.

Irie K, Nakagawa Y, Ohigashi H. Irie K, et al. Among authors: ohigashi h. Chem Rec. 2005;5(4):185-95. doi: 10.1002/tcr.20044. Chem Rec. 2005. PMID: 16041745 Review.

8

Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.

Nakagawa Y, Irie K, Yanagita RC, Ohigashi H, Tsuda K, Kashiwagi K, Saito N. Nakagawa Y, et al. Among authors: ohigashi h. J Med Chem. 2006 May 4;49(9):2681-8. doi: 10.1021/jm050857c. J Med Chem. 2006. PMID: 16640328

9

Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes. DGKgamma and DGKbeta are new targets of tumor-promoting phorbol esters.

Shindo M, Irie K, Masuda A, Ohigashi H, Shirai Y, Miyasaka K, Saito N. Shindo M, et al. Among authors: ohigashi h. J Biol Chem. 2003 May 16;278(20):18448-54. doi: 10.1074/jbc.M300400200. Epub 2003 Mar 5. J Biol Chem. 2003. PMID: 12621060 Free article.

10

Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

Morimoto A, Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, Fukuda H, Shimizu T, Shirasawa T. Morimoto A, et al. Among authors: ohigashi h. J Biol Chem. 2004 Dec 10;279(50):52781-8. doi: 10.1074/jbc.M406262200. Epub 2004 Sep 30. J Biol Chem. 2004. PMID: 15459202 Free article.

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