Spinal biopharmaceutics of bupivacaine and lidocaine by microdialysis after their simultaneous administration in rabbits.
Clément R, Malinovsky J, Le Corre P, Dollo G, Chevanne F, Le Verge R.
Clément R, et al.
Int J Pharm. 2000 Aug 10;203(1-2):227-34. doi: 10.1016/s0378-5173(00)00464-6.
Int J Pharm. 2000.
PMID: 10967444
The intrathecal bioavailability of bupivacaine and lidocaine was 12.3 and 17.9%, respectively, while it was 5.5 and 17.7% following the separate administration of each agent [Clement, R., Malinovsky, J.M., Le Corre, P., Dollo, G., Chevanne, F., Le Verge, R., …
The intrathecal bioavailability of bupivacaine and lidocaine was 12.3 and 17.9%, respectively, while it was 5.5 and 17.7% following the sepa …