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Therapeutic vaccination with MVA E2 can eliminate precancerous lesions (CIN 1, CIN 2, and CIN 3) associated with infection by oncogenic human papillomavirus.
Corona Gutierrez CM, Tinoco A, Navarro T, Contreras ML, Cortes RR, Calzado P, Reyes L, Posternak R, Morosoli G, Verde ML, Rosales R. Corona Gutierrez CM, et al. Among authors: posternak r. Hum Gene Ther. 2004 May;15(5):421-31. doi: 10.1089/10430340460745757. Hum Gene Ther. 2004. PMID: 15144573 Clinical Trial.
Clinical protocol. A phase II study: efficacy of the gene therapy of the MVA E2 recombinant virus in the treatment of precancerous lesions (NIC I and NIC II) associated with infection of oncogenic human papillomavirus.
Corona Gutierrez CM, Tinoco A, López Contreras M, Navarro T, Calzado P, Vargas L, Reyes L, Posternak R, Rosales R. Corona Gutierrez CM, et al. Among authors: posternak r. Hum Gene Ther. 2002 Jun 10;13(9):1127-40. doi: 10.1089/104303402753812520. Hum Gene Ther. 2002. PMID: 12067445 Clinical Trial. No abstract available.