Pratt WB - Search Results

1

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

Murphy PJ, Galigniana MD, Morishima Y, Harrell JM, Kwok RP, Ljungman M, Pratt WB. Murphy PJ, et al. Among authors: pratt wb. J Biol Chem. 2004 Jul 16;279(29):30195-201. doi: 10.1074/jbc.M403539200. Epub 2004 May 15. J Biol Chem. 2004. PMID: 15145929 Free article.

2

hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.

Billecke SS, Bender AT, Kanelakis KC, Murphy PJ, Lowe ER, Kamada Y, Pratt WB, Osawa Y. Billecke SS, et al. Among authors: pratt wb. J Biol Chem. 2002 Jun 7;277(23):20504-9. doi: 10.1074/jbc.M201940200. Epub 2002 Mar 28. J Biol Chem. 2002. PMID: 11923316 Free article.

3

Mutations at positions 547-553 of rat glucocorticoid receptors reveal that hsp90 binding requires the presence, but not defined composition, of a seven-amino acid sequence at the amino terminus of the ligand binding domain.

Kaul S, Murphy PJ, Chen J, Brown L, Pratt WB, Simons SS Jr. Kaul S, et al. Among authors: pratt wb. J Biol Chem. 2002 Sep 27;277(39):36223-32. doi: 10.1074/jbc.M206748200. Epub 2002 Jul 26. J Biol Chem. 2002. PMID: 12145311 Free article.

4

Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain.

Galigniana MD, Harrell JM, Murphy PJ, Chinkers M, Radanyi C, Renoir JM, Zhang M, Pratt WB. Galigniana MD, et al. Among authors: pratt wb. Biochemistry. 2002 Nov 19;41(46):13602-10. doi: 10.1021/bi020399z. Biochemistry. 2002. PMID: 12427021

5

Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft.

Murphy PJ, Morishima Y, Chen H, Galigniana MD, Mansfield JF, Simons SS Jr, Pratt WB. Murphy PJ, et al. Among authors: pratt wb. J Biol Chem. 2003 Sep 12;278(37):34764-73. doi: 10.1074/jbc.M304469200. Epub 2003 Jun 13. J Biol Chem. 2003. PMID: 12807878 Free article.

6

The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex.

Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. Morishima Y, et al. Among authors: pratt wb. J Biol Chem. 2003 Dec 5;278(49):48754-63. doi: 10.1074/jbc.M309814200. Epub 2003 Sep 24. J Biol Chem. 2003. PMID: 14507910 Free article.

7

Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts.

Thomas M, Dadgar N, Aphale A, Harrell JM, Kunkel R, Pratt WB, Lieberman AP. Thomas M, et al. Among authors: pratt wb. J Biol Chem. 2004 Feb 27;279(9):8389-95. doi: 10.1074/jbc.M311761200. Epub 2003 Dec 11. J Biol Chem. 2004. PMID: 14670946 Free article.

8

Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus.

Galigniana MD, Harrell JM, O'Hagen HM, Ljungman M, Pratt WB. Galigniana MD, et al. Among authors: pratt wb. J Biol Chem. 2004 May 21;279(21):22483-9. doi: 10.1074/jbc.M402223200. Epub 2004 Mar 5. J Biol Chem. 2004. PMID: 15004035 Free article.

9

Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation.

Galigniana MD, Harrell JM, Housley PR, Patterson C, Fisher SK, Pratt WB. Galigniana MD, et al. Among authors: pratt wb. Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):27-36. doi: 10.1016/j.molbrainres.2003.12.015. Brain Res Mol Brain Res. 2004. PMID: 15046863

10

The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.

Billecke SS, Draganov DI, Morishima Y, Murphy PJ, Dunbar AY, Pratt WB, Osawa Y. Billecke SS, et al. Among authors: pratt wb. J Biol Chem. 2004 Jul 16;279(29):30252-8. doi: 10.1074/jbc.M403864200. Epub 2004 May 19. J Biol Chem. 2004. PMID: 15155759 Free article.

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