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Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain.
Sapparapu G, Planque SA, Nishiyama Y, Foung SK, Paul S. Sapparapu G, et al. Among authors: paul s. J Biol Chem. 2009 Sep 4;284(36):24622-33. doi: 10.1074/jbc.M109.011858. Epub 2009 Jun 19. J Biol Chem. 2009. PMID: 19542217 Free PMC article.
V(L) domains catalyze peptide bond hydrolysis independent of V(H) domains (Mei, S., Mody, B., Eklund, S. H., and Paul, S. (1991) J. Biol. Chem. 266, 15571-15574). V(H) domains bind antigens noncovalently independent of V(L) domains (Ward, E. S., …
V(L) domains catalyze peptide bond hydrolysis independent of V(H) domains (Mei, S., Mody, B., Eklund, S. H., and Paul, …
Constant domain-regulated antibody catalysis.
Sapparapu G, Planque S, Mitsuda Y, McLean G, Nishiyama Y, Paul S. Sapparapu G, et al. Among authors: paul s. J Biol Chem. 2012 Oct 19;287(43):36096-104. doi: 10.1074/jbc.M112.401075. Epub 2012 Sep 4. J Biol Chem. 2012. PMID: 22948159 Free PMC article.
6,356 results