Rossman KL - Search Results

1

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.

Lu M, Kinchen JM, Rossman KL, Grimsley C, deBakker C, Brugnera E, Tosello-Trampont AC, Haney LB, Klingele D, Sondek J, Hengartner MO, Ravichandran KS. Lu M, et al. Among authors: rossman kl. Nat Struct Mol Biol. 2004 Aug;11(8):756-62. doi: 10.1038/nsmb800. Epub 2004 Jul 11. Nat Struct Mol Biol. 2004. PMID: 15247908

2

A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.

Lu M, Kinchen JM, Rossman KL, Grimsley C, Hall M, Sondek J, Hengartner MO, Yajnik V, Ravichandran KS. Lu M, et al. Among authors: rossman kl. Curr Biol. 2005 Feb 22;15(4):371-7. doi: 10.1016/j.cub.2005.01.050. Curr Biol. 2005. PMID: 15723800 Free article.

3

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J. Snyder JT, et al. Among authors: rossman kl. Nat Struct Biol. 2002 Jun;9(6):468-75. doi: 10.1038/nsb796. Nat Struct Biol. 2002. PMID: 12006984

4

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.

Rossman KL, Der CJ, Sondek J. Rossman KL, et al. Nat Rev Mol Cell Biol. 2005 Feb;6(2):167-80. doi: 10.1038/nrm1587. Nat Rev Mol Cell Biol. 2005. PMID: 15688002 Review.

5

RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.

Cheng L, Rossman KL, Mahon GM, Worthylake DK, Korus M, Sondek J, Whitehead IP. Cheng L, et al. Among authors: rossman kl. Mol Cell Biol. 2002 Oct;22(19):6895-905. doi: 10.1128/MCB.22.19.6895-6905.2002. Mol Cell Biol. 2002. PMID: 12215546 Free PMC article.

6

Crystal structure of the DH/PH fragment of Dbs without bound GTPase.

Worthylake DK, Rossman KL, Sondek J. Worthylake DK, et al. Among authors: rossman kl. Structure. 2004 Jun;12(6):1078-86. doi: 10.1016/j.str.2004.03.021. Structure. 2004. PMID: 15274927 Free article.

7

Larger than Dbl: new structural insights into RhoA activation.

Rossman KL, Sondek J. Rossman KL, et al. Trends Biochem Sci. 2005 Apr;30(4):163-5. doi: 10.1016/j.tibs.2005.02.002. Trends Biochem Sci. 2005. PMID: 15817389 Review.

8

The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity.

Baumeister MA, Rossman KL, Sondek J, Lemmon MA. Baumeister MA, et al. Among authors: rossman kl. Biochem J. 2006 Dec 15;400(3):563-72. doi: 10.1042/BJ20061020. Biochem J. 2006. PMID: 17007612 Free PMC article.

9

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.

Mitin N, Betts L, Yohe ME, Der CJ, Sondek J, Rossman KL. Mitin N, et al. Among authors: rossman kl. Nat Struct Mol Biol. 2007 Sep;14(9):814-23. doi: 10.1038/nsmb1290. Epub 2007 Aug 19. Nat Struct Mol Biol. 2007. PMID: 17704816 Free PMC article.

10

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

Worthylake DK, Rossman KL, Sondek J. Worthylake DK, et al. Among authors: rossman kl. Nature. 2000 Dec 7;408(6813):682-8. doi: 10.1038/35047014. Nature. 2000. PMID: 11130063

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