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An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11.
Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. Wierdl M, et al. Among authors: hyatt jl. Cancer Gene Ther. 2008 Mar;15(3):183-92. doi: 10.1038/sj.cgt.7701112. Epub 2008 Jan 11. Cancer Gene Ther. 2008. PMID: 18188187
Discovery of novel selective inhibitors of human intestinal carboxylesterase for the amelioration of irinotecan-induced diarrhea: synthesis, quantitative structure-activity relationship analysis, and biological activity.
Wadkins RM, Hyatt JL, Yoon KJ, Morton CL, Lee RE, Damodaran K, Beroza P, Danks MK, Potter PM. Wadkins RM, et al. Among authors: hyatt jl. Mol Pharmacol. 2004 Jun;65(6):1336-43. doi: 10.1124/mol.65.6.1336. Mol Pharmacol. 2004. PMID: 15155827
The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action.
Harel M, Hyatt JL, Brumshtein B, Morton CL, Yoon KJ, Wadkins RM, Silman I, Sussman JL, Potter PM. Harel M, et al. Among authors: hyatt jl. Mol Pharmacol. 2005 Jun;67(6):1874-81. doi: 10.1124/mol.104.009944. Epub 2005 Mar 16. Mol Pharmacol. 2005. PMID: 15772291
Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice.
Morton CL, Iacono L, Hyatt JL, Taylor KR, Cheshire PJ, Houghton PJ, Danks MK, Stewart CF, Potter PM. Morton CL, et al. Among authors: hyatt jl. Cancer Chemother Pharmacol. 2005 Dec;56(6):629-36. doi: 10.1007/s00280-005-1027-y. Epub 2005 May 26. Cancer Chemother Pharmacol. 2005. PMID: 15918039
Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan.
Tyminski E, Leroy S, Terada K, Finkelstein DM, Hyatt JL, Danks MK, Potter PM, Saeki Y, Chiocca EA. Tyminski E, et al. Among authors: hyatt jl. Cancer Res. 2005 Aug 1;65(15):6850-7. doi: 10.1158/0008-5472.CAN-05-0154. Cancer Res. 2005. PMID: 16061668
Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11.
Hyatt JL, Tsurkan L, Morton CL, Yoon KJ, Harel M, Brumshtein B, Silman I, Sussman JL, Wadkins RM, Potter PM. Hyatt JL, et al. Chem Biol Interact. 2005 Dec 15;157-158:247-52. doi: 10.1016/j.cbi.2005.10.033. Epub 2005 Oct 28. Chem Biol Interact. 2005. PMID: 16257398
44 results