Hurst S - Search Results

1

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios.

Williams JA, Hyland R, Jones BC, Smith DA, Hurst S, Goosen TC, Peterkin V, Koup JR, Ball SE. Williams JA, et al. Among authors: hurst s. Drug Metab Dispos. 2004 Nov;32(11):1201-8. doi: 10.1124/dmd.104.000794. Epub 2004 Aug 10. Drug Metab Dispos. 2004. PMID: 15304429 Review.

2

A significant drug-metabolizing role for CYP3A5?

Williams JA, Cook J, Hurst SI. Williams JA, et al. Drug Metab Dispos. 2003 Dec;31(12):1526-30. doi: 10.1124/dmd.31.12.1526. Drug Metab Dispos. 2003. PMID: 14625349 Review.

3

Reaction phenotyping in drug discovery: moving forward with confidence?

Williams JA, Hurst SI, Bauman J, Jones BC, Hyland R, Gibbs JP, Obach RS, Ball SE. Williams JA, et al. Curr Drug Metab. 2003 Dec;4(6):527-34. doi: 10.2174/1389200033489235. Curr Drug Metab. 2003. PMID: 14683480 Review.

4

In vitro ADME phenotyping in drug discovery: current challenges and future solutions.

Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L, Sahi J. Williams JA, et al. Among authors: hurst s. Curr Opin Drug Discov Devel. 2005 Jan;8(1):78-88. Curr Opin Drug Discov Devel. 2005. PMID: 15679175 Review.

5

Udp-glucuronosyltransferase 2b7 is the major enzyme responsible for gemcabene glucuronidation in human liver microsomes.

Bauman JN, Goosen TC, Tugnait M, Peterkin V, Hurst SI, Menning LC, Milad M, Court MH, Williams JA. Bauman JN, et al. Drug Metab Dispos. 2005 Sep;33(9):1349-54. doi: 10.1124/dmd.105.005108. Epub 2005 Jun 24. Drug Metab Dispos. 2005. PMID: 15980101

6

Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid.

Goosen TC, Bauman JN, Davis JA, Yu C, Hurst SI, Williams JA, Loi CM. Goosen TC, et al. Drug Metab Dispos. 2007 Aug;35(8):1315-24. doi: 10.1124/dmd.107.015230. Epub 2007 Apr 30. Drug Metab Dispos. 2007. PMID: 17470524

7

Impact of physiological, physicochemical and biopharmaceutical factors in absorption and metabolism mechanisms on the drug oral bioavailability of rats and humans.

Hurst S, Loi CM, Brodfuehrer J, El-Kattan A. Hurst S, et al. Expert Opin Drug Metab Toxicol. 2007 Aug;3(4):469-89. doi: 10.1517/17425225.3.4.469. Expert Opin Drug Metab Toxicol. 2007. PMID: 17696800 Review.

8

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction.

Youdim KA, Zayed A, Dickins M, Phipps A, Griffiths M, Darekar A, Hyland R, Fahmi O, Hurst S, Plowchalk DR, Cook J, Guo F, Obach RS. Youdim KA, et al. Among authors: hurst s. Br J Clin Pharmacol. 2008 May;65(5):680-92. doi: 10.1111/j.1365-2125.2007.03070.x. Epub 2008 Feb 14. Br J Clin Pharmacol. 2008. PMID: 18279465 Free PMC article.

9

Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.

Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA. Dalvie D, et al. Among authors: hurst s. Chem Res Toxicol. 2009 Feb;22(2):357-68. doi: 10.1021/tx8004357. Chem Res Toxicol. 2009. PMID: 19146377

10

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction.

Fahmi OA, Hurst S, Plowchalk D, Cook J, Guo F, Youdim K, Dickins M, Phipps A, Darekar A, Hyland R, Obach RS. Fahmi OA, et al. Among authors: hurst s. Drug Metab Dispos. 2009 Aug;37(8):1658-66. doi: 10.1124/dmd.108.026252. Epub 2009 Apr 30. Drug Metab Dispos. 2009. PMID: 19406954

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